Episode 155 - Complete

Vinny Welsby56min

Speaker 100:00

You're listening to the face value podcast episode 155 is we go v z Olympic the miracle weight loss drug it's made out of let's do it

Speaker 100:26

Hello, welcome to this episode. I'm your host, Vinny Welsby. Pronouns they them. Coming to you from the traditional ancestral and unceded territory of the Coast Salish people's Squamish slaver tooth, and Musqueam nations. We have a jam packed episode today. In fact, I think I'm gonna have to split it into two. I've don't think I've ever done a to two parter before. Yeah, so it's giant. Before we start just a kind of a note on last episode about fat bias in the media. Some of the It's come to my attention is that I noted that Rebecca Poole was the most quoted person and in regards to academics, and and I said that she was seen and I think I said something like, Well, you know, at least she's fighting the good fight and something like that. Not those exact words, but actually, I found out she is in and also she is one of the people who is touting fatness as a disease rhetoric, or up wah, wah. So she is one of those people who say, be nice to fat you say can't help being fat and greedy. So yeah, I take back saying hey, well, Alicia is on our side kind of thing. She's not so anyway, so today we are talking about all of the stuff that you might have been seeing on the internet, maybe you've you've experienced it in your life or seen friends and family start taking weight loss drugs because in the last couple of years we've had a big uptick in awareness of these new drugs than I actually know but new new dosing and marketing for weight loss and yeah, like what what do we know about it and I've spoken about we go V like two years ago when it had just been in 2021 when it had just been approved by the FDA.

Unknown03:02

And

Speaker 103:03

and so I was like I spoke about this like three minutes ago but I mean Jesus Christ time goes really quick. But now we've had a little bit of time for the marketing machine to do its work and for the drug to get into people's hands and see what's happening. And so let's talk about it and all the different kinds of different names and variations and and all that type of stuff this episode I don't know if you can hear it in the background but my computer my laptop my MacBook Air it's fighting for its life the fan is going because this document that I have in in Google in Google notes is absolutely huge and it's so big my computer's like no Why Why are you giving us as one of the major non stop at which goes to show the amount of research that has gone into this episode it's been two full days plus extra hours here and there researching this podcast so it's a been a big undertaking for me and and if that's something that you appreciate and you appreciate me producing a free podcast for you where we have no adverts and consider giving a donation, buy a cup of coffee, a cup of tea whatever for me on Koh Phi or Kofi rather, I just want to say Ko Phi Ko Phi just sounds right right. But anyway Kofi ko if I face Valley link in the show notes. There you can do a one time donation or five bucks or if you would like the size diversity resource guide, you can set up a a monthly donation for five bucks or 10 bucks or 20 bucks. You'll get extra perks if you choose the higher levels. The size of Su resort guide guide is awesome but want to say but it is full stop. And so if you appreciate this work of activism for free, and me taking like 75 years of my life to do the research, and exposed myself to these doctors on tick tock, I'm traumatized. And if that is something that you you can do, then I would really, really appreciate it. Okay, so what we're gonna be talking about probably over these two episodes, because it's so gigantic is one what is we go vi slash as Empik slash semaglutide. Slash all of the other names that we have out there, who are Novo Nordisk the manufacturers. Overview of the drugs, review of the research, the marketing using weight stigma, supply issues and celebrities using it. Personal stories from those who have used it, Novo Nordisk lawsuits and scandals, other new drugs, plus size influences and tick tock and finally, so what's the solution? And trigger warning for these episodes? Why are we mentioning poor outcomes slash side effects that include suicide ideation? Digestive type issues. Is there any other trigger warning? So I should mention, I mean, well, you know, just the whole anti fatness of the thing and the whole depressing nature that these drugs exist. So if any of that is not feeling good for you, then skip this episode, as well, when I come to this one story, which is a little bit more kind of mentions a little bit more in detail, and I'll just do a trigger one before that. So if that's just one thing, that's not feeling good for you, then the one thing is about, like digestive stuff, so I'll do it. I'll do it before. I'll do another little one before that if you want to skip that bit. Okay, so basically this whole weight loss drug thing. It's not new. We've been we've been weight loss drugs have been around for ages, but weight loss drugs as a concept. There they are based on a set of faulty presumptions and those faulty biz op presumptions that have led to our current waste weight loss drugs, six of them. Number one, these drugs are created based on the belief that having a fat body is unhealthy and an desirable Okay, so that is a faulty assumption. Fat people can be healthy, then people can be unhealthy fat bodies are not diseased things that need to

Unknown08:01

not exist.

Speaker 108:03

Number two, it presumes that making a body smaller will mean that body is now healthy and desirable. What we know about weight loss is that it's not the actual weight loss that increases health. It's health promoting behaviors that might have been engaged in during that weight loss and then it's prescribed a weight loss. Yeah, number three, but any means necessary to obtain a smaller body is tolerable, as fatness is so abhorrent and an unhealthy you'll see stories here today from folks whose doctors seem to absolutely not give a shit what happens to them as long as they're a few pounds small. The next assumption is that the solution to anti fat bias is erasing the world of fat people. So you'll see in our episode is is that Novo Nordisk the marketing. The marketing company, might as well call it a marketing company, the pharmaceutical company behind these drugs have co opted fat liberatory language and because we're getting smarter when it comes to marketing, they're not saying you know, fat people are subhuman, like what they probably have done in the past. They're saying that it's not fat people's fault. Therefore, we should get them the treatment that they need to no longer be a fat person and read the planet of these poor diseased souls. The next assumption is that fat people are fat because they eat too much and therefore if they eat less, and exercise more than they will be thin. So these drugs up and appetite suppressants, fat people are fat for many, many different reasons and appetite suppressants. What is another word for an appetite suppressant a diet and as we have seen with 100 years of data suppressing your appetite does not lead to good outcomes or weight loss finally, Number Six being temporarily smaller is worse worth risking the lives and quality of lives of fat people because spoiler these drugs are made for temporary small amounts of weight loss but that doesn't matter because if you were temporarily five pounds smaller and you died in the process at least you died five pounds lighter

Speaker 110:59

Okay, and so then the solution to this to this supposed problem of fatness is weight loss injections, manufactured by Novo Nordisk called semaglutide liraglutide Zan pick Victoza saxenda We go V. The different names in different markets and the names of the drugs and the names of the marketing the what they're marketed as different in different areas and we'll talk about that. So, we're just going to focus on calling it we go V and unexplained about the different things good right? Well, I've heard it ozempic And why you might have heard heard different things and what it all of what it is. So what is a we go Vic? So we go Vic, we go v ozempic. There we go. That's a new with a new name for it. We go Vic, so we go V so zen Peck or Ribet Reibel HSAs are diabetes drugs. The drug that is in there is called semaglutide.

Unknown12:18

They

Speaker 112:19

noticed the drug manufacturer that folks lost a little bit of weight while taking this DIB BTS drug. There's also another one called Vic Tozeur. liraglutide and so what it is, is a

Unknown12:45

glucagon

Speaker 112:46

like peptide one, agonist, also known as G L p one. So you're going to hear that more and more if you're not familiar with that phrase, you're going to hear that more and more because that is what these weight loss drugs are. So GLP one is a hormone that your body makes naturally and it's responsible for stimulating insulin release. And so for folks who have been taking ozempic

Unknown13:19

Reibel cysts osis

Speaker 113:21

Victoza and though medication in those brand names, the medication in the brand names semaglutide. liraglutide okay.

Unknown13:34

They are all for

Speaker 113:35

diabetes. Now, Novo Nordisk that drug manufacturer has rebranded the exact same drug giving it the double a double dose of the drug. And given it that name, we go v. So we go V is basically a Zen pick but a different name and double the dose and sack sender is Victoza another diabetes drug but double the dose. Okay. So, Zen pick is for a diabetics and then the same exact same drug double the dose called we go V marketed to fat people. Okay, so what it does is it is an appetite suppressant and it makes you feel fun on longer. So slow as your your digestive so as Empik and riderless, which is the diabetes drugs aren't approved for people without diabetes.

Unknown14:47

saxenda

Speaker 114:50

is the other weight loss branded is also a GLP one agonist and it's also FDA approved And it came before we go v. So saxenda The difference is it came before and the trials showed a little bit of weight loss. Same company, you know, Vinod Nordisk then came up with we go v. And the weight loss results were a little bit bigger. So that's why, you know, saxenda has been around longer, but less people are probably aware of saxenda and probably less people are probably taking it because the results from weego V, you know, the marketing machine from Novo Nordisk because it said, it's like the most astonishing results that you've ever heard. Let's see if they are astonishing results. So

Unknown15:53

to get

Speaker 115:55

we go V. In the United States, someone needs to be have a BMI of I'm going to mention numbers here BMI numbers, so skip skip over a minute or so, if you don't want to hear that needs to have a BMI of 2727 and let me look at my other document. So many of these things. Yep. 27 and have at least one quote, weight related co morbidity, a comorbidity is the simultaneous presence of two or more diseases or medical conditions in a patient. So the examples here that they are saying are weight related is hypertension, type two diabetes. This lipid idemia which is to do with your your lipids and stuff, and sleep apnea. If you look at the Hayes health sheets, you'll see that none of these are caused by fatness type three diabetes is largely a genetic condition. Sleep apnea is to do with your facial structure and your bone structure.

Unknown17:16

Just eyeroll

Speaker 117:17

or so if you're a BMI of 27 and you have one comorbidity which is you know, just basically just being a human or if you have a BMI of 30 and no issues and so, if you have a BMI of 30 which is by the way, very small, they are telling us that it's okay to de risk the lives of fat people you know, or just being in a fat body of a BMI 30 is allegedly just making being a being a disease state. So doesn't matter if you're healthy, you're fat, so get on this fucking drug. Okay, so that's a little overview of like the basics of the drug we're gonna get in a little deeper, but who are Novo Nordisk? So Novo Nordisk is a pharma company and a quote from Louise from the untrapped podcast if you don't listen to that podcast is great. You should go listen to it. So Novo Nordisk pharma company built their fortune on insulin, which was a discovery made back in the 1920s by Canadian scientists, William Banting, and his colleagues and they believe that insulin should be cheaply made to as many people as possible in the hope of curing and managing diabetes. Yes, William Banting. And so in line with this really wonderful belief, they sold the patent for insulin to the University of Toronto for just $1 Amazing Love it. In 1923, a Danish scientists, Auguste CRO, obtained the rights to manufacture insulin in Europe, and he set up the company that would later become Novo Nordisk, and literally since then, Novo has been steadily running ruining Banting the legacy by driving up the cost of insulin. And so this company has been in the news a lot in the last few years, because they are then Eli Lilly, and another, I can't remember the name. They have been in price fixing fixing scandal where the cost of this medication now is so high, they watch each other how much they're charging, and they basically keep, you know, step in step with each other, increasing the price, astronomically. And this is in the US, right? In other places. No, they're not allowed to do that because of the beautiful laws that those countries have in place that don't allow this bullshit system setup where where manufacturers drug manufacturers can charge what they want. Other countries have controls in place where they say we're willing to pay this much and this is how much it is and the customer is The the health care providers not the individual patients and so here the customers are the patients right? In the US, I'm going to say here I'm in Canada. So Novo Nordisk we'll get into the scandals later, but it's a company that's faced multiple lawsuits and penalties for misleading the public about their drugs, their side effects and misleading their investors about

Unknown20:27

the

Speaker 120:29

return on on on money that they're going to get. And because of that, there was a big scandal a couple of years ago, and the US government got involved and was like, what's all this you're charging everyone too much? And they were like, oh, whoopsie and so nothing really happened. Like they didn't they didn't suddenly be like, Oh, if I get that, you know, let's make it 10 cents for for a drug whatever. They instead knew that their their capacity to make gobs of money from diabetes was limited, instead of like gobs gobs, gobs, and gobs. And gobs is just gobs gobs gobs, and so they been making a huge push push into fatness. And that is just like a cash cow, right? If you're able to treat quote unquote treat fatness, then I mean, that's it instance, billions of dollars of revenue. So how does this drug work? Okay, there we go V semaglutide, whatever you want to call it, as Empik. So this drug basically triggers the type of cell in the pancreas called the beta cells, and the beta cells job is to produce insulin. And this is great for those who have diabetes, as their B cells are not producing enough insulin. So what they notice when they were treating people with diabetes is that they happen to lose a little bit of weight. And so Novo Nordisk said, we like that losing a little bit of weight. How can we make it so that they lose lots of weight, double the dose? And so that's what they have done is they have doubled the dose of this diabetes medication and give it to those without diabetes. So Dr. Fee, Willa, you can find her Fiona Willa on the Instagrams. Quote from her my great fear is that because it tickles those these beta cells, and actually probably much a much more apt term for the double dose is Hamer's the beta cells, that they're going to be exhausted much sooner than they otherwise would. And what that does is turned people that didn't have diabetes into people with diabetes. And now need insulin, these weight loss drugs from Novo Nordisk potentially creating lifelong customers beyond when they have stopped taking the drugs, and they've extended the market. So there's people that would normally be their customers wouldn't normally be their customers, because their main customer base is people with diabetes requiring insulin. And so what Dr. Fie is saying here is that it's triggering the cells to do something that they don't need, and with the double dose, so we don't need the normal dose that diabetes patients would need, instead of even just that a double dose. And so I was like, I like trying to make this as simple as possible. And so we're gonna visualize this all right, we're gonna visualize this and so this visualization might not be perfectly accurate because I'm, I'm describing Julian, my Michael in this visualization as as, as semaglutide. So, okay, so imagine a Betta cell. I'm just gonna imagine a cell that looks like kind of like a red blood cell, it doesn't look like they can, whatever. So imagine a Betta cell whatever you imagine a cell that looks like in a beta cell is out running out in a race Okay? Out in real life running. Got the trainer's on sweatband, whatever so beta cell is running in a race and it's pretty tired, right? Something's gone on in that beater cell and it's tired. And so semaglutide Who is that betta cells really sweet trainer, someone who is like so you know, gentle and kind, comes along with a with a beta cell and says, Hey, here's a sport sports drink for you and says you can do it you can finish that race and the beta cells Thank you so much has a drink of that, that sports drink and finishes, finishes the race happy. This is a really like basic, basic visual, right? You know, it's way more complicated than that, right?

Unknown25:13

And,

Speaker 125:14

you know, so So the betta cell is tired, it's not working correctly for whatever reason. And then the medication comes along, gives it what what it wants it needs, what it needs stimulates it helps it out. And then it does the thing that it wants to do, right? So if we imagine now what we go V is, and so that's the diabetes medication, right? There's an issue where we, we need to give medicine to fix the issue. And everyone's happy. In a roundabout way, obviously, that's not always what happens. But so now, let's put that trainer that was previously really sweet and nice, and you know, just positive and wonderful. Let's put that trainer on steroids. Let's turn that trainer into Jillian Michaels from The Biggest Loser. And she's mean, and the betta cell that Julian McMichaels, aka semaglutide is training is not in they're not even not even their client. There's a beta cell who's running in the race and is doing really well isn't struggling is happy. They're in the top of the pack. And Jillian McMichaels is like right, I'm going to take it upon myself to go and train that betta cell who I don't like the look of and so Jillian Michaels, runs along to the beta cell, gets out the sports drink and just throws it at the back of her head of the beta cell. And the beta cell is like what the hell and then Julie McMichaels is like drink 10 of those drinks in a row and you've been a guzzle them down and the the betta sellers like, kind of scared and been like, Oh, okay. And then Jillian Michaels that the semaglutide is saying Now kick up your legs and and do some jumping jacks while you're running and do a burpee as well. And so the beater cell finishes the race, but his tie yurts and it's been given all of those those drinks that it was like I'm I mean, I didn't even need anyone on the one of them to throw in the back of my head. And like what the hell that was really, I didn't like that the beta cell could have very comfortably finished that race. But now every race, Julian McMichaels, aka semaglutide is harassing the beta cell, the beta cell will finish the race, but eventually will turn into a genuinely tired beta cell. And then that's when we go back into that original nice trainer that's helping the tired beta cell, because that beta cell is now in the body of someone who has diabetes, because of what Julian McMichael aka semaglutide. The drug that's in we go V has done. Right. So that that's, that's like storytime for you, that is like, you know, very, very rough, very rough idea. And, you know, there's probably lots of holes in that, that very ridiculous example of what that looks like. But you can see why harassing and poking and stimulating these betta cells when there's nothing wrong with them can be problematic. So that is the mechanism of what's happening. And from that, what what happens is, there is appetite suppressants happening in the body and so your brain is like, I'm not that hungry. When you do eat, you're less. You eat, we eat less because you're less hungry. And also the sits the food sits in your digestive system for longer. And there's a lot of problems with that stuff, right? And I'm, you know, I'm telling this stuff and I don't want people to be like, Oh, sounds good. I'm going to go get it. Keep listening to the episode. Okay, so let's look at the science. All right. Now. So we've if we just imagine it, we've got Novo Nordisk at the top as the manufacturer, and then there are two big drugs. The brand name for those diet version of the drugs is saxenda. And we go V. Depending on where you live, you might say we got v. I don't know how you'd say saxenda. differently. Sacks, and I don't know. So they did randomized control trials for both of these drugs. And so we have a lot And I've kind of similar outcomes for both. And so I'm going to give you all of the similar the similar outcomes for both and then and then split it into two and say, What's the difference between success? And and what's, what's different with we go V? Okay. So both? I would say both or because there were there was a few studies in with the published papers, right, the published trials. If you want a good trial paper study about a drug, who would you want to be doing that, you know, drug that can be a drug that has historically been very, very dangerous weight loss drugs in the past have been very dangerous and have been pulled from the market, you would want scientists who have no connection to the drug manufacturers, and who are not influenced by them as much as possible. So some neutral third party, we do not have that here. The trial was planned and funded by novo. And almost every single author has a conflict of interest. They're on the payroll. And so with the SEC sender, all but two, we've been paid by we go V and on by novo, and with the weego V, every single author was on the payroll of Novo. So you can see that that is a conflict of interest there, you're being paid by this company, might you be a little bit influenced by that. And so,

Unknown31:53

it's a

Speaker 131:56

successor is a daily injection, we go V is a weekly indirect injection. Both the trials the majority of the participants were white women in their mid 40s with a BMI of 38. So small for a drug to be labeled as a weight loss drug, the minimum requirements that that people who take that drug, it need to lose if 5% More than the placebo group, okay. So to be able to be allowed to be marketed as a weight loss drug versus you know, this is just a placebo is 5% 5% of the of their bodyweight. saxenda Julia scraped through that requirement she just scraped through so it's they're barely legally are allowed to call it a weight loss drug but you bet those motherfuckers are calling it a weight loss drug. They're like the best weight loss drug and weight regain happens for both drugs as soon as the drug is stopped, or they're given a placebo. We have pancreatitis markers increased with both drugs. The most common side effects are nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, upset stomach, dizziness, feeling bloated belching, glass, gas, stomach flu and heartburn. So people who stayed on SEC sender for another three months post the end of the trial, so some people are not at the end of the trial, but some people will put on a placebo and some people were still taking six Ender for another three months, we're beginning to put weight back on even though they were still taking the drug. No surprise, surprise. So even if you're still taking the drug, you'll be getting to put weight back on and then they stopped the trial because we didn't want to see the rest of what happens that way. Because that's what was gonna happen. They're gonna keep putting weight on. Both needs to be taken for the rest of your life. So in the US, that's $1,300 a month in Canada, that's $400 a month, or $4,726 a year. If you were in the US and you are on it for 25 years as an example that's going to be half a million dollars spent on this drug because it is a life long commitment. It is not covered by insurance because it has not been shown to work it has not been shown to improve health. So many countries have denied to cover it as they have no evidence that improves health markers. And if you are taking it for for life or even an extended time, months years, it means that you're being exposed to the harmful side effects for longer. Both medications have box warnings, you're when I say box warnings, commonly known as blackbox warnings, which is the highest level of warning from the FDA for cancer risk. So that's the most, you know, without FDA not approving it, then the sternness the highest level warning is when they have box warnings. We mentioned before that for those without diabetes, both drugs will probably speed up diabetes progression, or even manufacture diabetes. However, we're not sure of the effect Exactly. As we have no long term data. You know, where we're going to get that long term data from is the poor souls who are taking it. So Regan Chastain, here's a quote from Reagan in other studies of similar GLP one agonists, we have seen that higher amounts of weight loss are predicated by longer on set of gastro intestinal symptoms. So there is some question as to how much of the weight loss is the action of the drug on hormones and slow digestive motility and how much is about giving people flu like symptoms? Also, a bit in regards to who gets to who, who is prescribed to there is a lower BMI threshold for people who come from Asian Chinese, black, African or Caribbean family

Unknown36:51

backgrounds

Speaker 136:53

because over racism and you know, why is that racist is because people who have higher weights in those communities, a lot of what causes higher weight is stress is oppression is stigma. And they are experiencing racism and so to cure the racism that they're experiencing, let's make them thinner. Good idea. Not not. Okay, so this the summary of the drugs that we're gonna go into specifically here is provided by Louise Adams from all fired up podcast who, who looked at the studies and summarized exactly what was in there. So first, we have a sack sender, aka Victoza liraglutide. You Yeah. And again, so it's liraglutide, but the higher dose. So it's injected daily. In 2014, saxenda, became the first medication of its kind to be approved for weight loss in people without diabetes. So the trial was published in 2015. In the New England Journal of Medicine, the trial was 56 weeks long.

Unknown38:15

Red flag, number one,

Speaker 138:19

weight loss trials, weight loss studies need to be minimum five years long. Because what we know is that weight loss begins to fail at year two,

Unknown38:33

three onwards.

Speaker 138:37

So to really know what this if this drug is going to produce weight loss, it needs to be five years 56 weeks, is four years less. So we don't have information. There was 3700 people in the study 2400 took the drug, and 1200 took the placebo. There was a 50% dropout rate. And of that 50% 1/3 dropped out because they were experiencing an manageable side effects. So already we have a huge numbers of people who are not able to tolerate the side effects. Were those people included in the data

Unknown39:25

near near

Speaker 139:30

in regards to where they were they included in the data to say here are examples of how our drug has failed. No. No, because that would skew the information that would that would suggest that the drug didn't work as well wouldn't it? So 80% of people had side effects 6% had serious side effects like gallstones, gastrointestinal issues, acute kidney injury, suicidal ideation and and behaviors, the average pulse rate of participants increased by 2.5 beats per minute. And their weight loss how much huge amounts of weight loss did they get for all of this absolute shitty side effects. People lost on average 8% of their weight over the 56 weeks. And so that's is around 18 pounds in total, which is 1.2 pound per month. Staggering, groundbreaking, incredible. 1.2 pounds per month. Oh my goodness. What we see though, with any diet, or any, any drug anything, is it was more weight loss at the beginning, and then it slows down. And so you might be like, Oh, well, I know, is a friend who lost 10 pounds in the first month. Or I know someone who lost No, no way. Or I know, someone who put on weight on this drug. The placebo group lost 2.6% of their body weight around 6.5 pounds. By the way, both groups were told that they needed to exercise, they needed to reduce their calorie consumption by 500 calories. And then they had a monthly check in with a coach. So it wasn't just the drugs,

Unknown41:35

right.

Speaker 141:39

It was also the fact that they were starving themselves and exercising. So the difference between 8% of their weight loss with people with the drugs and 2.6. So it caused like basically 5%, which is again, it's just just the threshold to be legally allowed to call themselves a weight loss drug 1/3 of people didn't lose the minimum requirement, which is a 5% of their body weight for the drug to be classed as a weight loss drug 10 Women who lost significant significant amount of weight were diagnosed with breast cancer. So leading to the assumption that the weight loss came from the cancer and not from the drug. And so we don't know if those 10 women, their data was taken out of the study. A lot of key information about the studies have been removed. We don't know. You know, it's kind of like, Oh, here's this and it's like, what will happen to them? Or this is this is how we this is how we are doing a study is kind of like this, go look over here to see how we're doing it. And then you look over there and it's there's no information. really poorly designed studies. Both of these are not replicable. So if what if someone wanted to go out and say I want to do an independent study, do an exact same what you have done here, that would not be able to do it with the information that that has been provided in the study because there's no there's no information on on the locations and where they are and what was done. And you know, we've got more broad information. Yep. So we got to be we got to be the one that's touted as the absolute in a box so we go be aka Zen pickers and pick as a diabetes version. We go via the weight loss version, it is injected weekly, a trial was published in the 2021 and 2021. In the New England Journal of Medicine, the trial was 68 weeks long, again, way under what we need. There were 1900 people and 1900 61 people in the study. 13 106 took the drug, and 655 took the placebo. One in five people were not able to take the injections. 95% of the participants had side effects 95% 10% had serious side effects. The same that we mentioned before, like pancreatitis, which can lead to pancreatic cancer, suicide ideation behaviors, acute kidney injury injury, so the difference between success under 80% had serious side effects. He didn't have side effects, we go v 95. Sucks Ender 6% had serious we go v 10%. So it was a lot more dangerous. Also the average pulse pulse rate increased by 3.5 beats per minute for sender is 2.5. Ideally it will be zero and The increased beats per minute. The average weight loss was Okay, get ready for this incredible weight loss, how much is it gonna be? Well, changing drug average weight loss was 1.9 pounds a month, over 68 Weeks was 33 pounds G Oh my God call the presses, which is what they did, they did that. And the reason why they called the presses because as we know, weight loss does not work. And so all of the additional weight loss methods don't work. And so any amount of weight loss is, you know, Holy fucking shit. This is amazing 33 pounds weight loss over 68 weeks now, to lose 1.99 pounds in a month, I just need to go and have a couple of big shifts, you know, am I wouldn't have all of this other stuff, you know, risk of cancer and throwing up all the time and you'll see what what happens to people in real life. So we went on so the study went on for 68 weeks, but what happened at week 60 Weight Loss had plateaued, then the study was stopped at week 68 Presumably because then the weight loss would continue going up. You know, it's like the neck tick. That's kind of like what weight loss is any type of weight loss, the starting weight go down and then slowly go up. And then the next diet or weight loss thing go down, so lowly go up. And so workbook pop up and of course there's nothing wrong with having a higher weight. And this is what weight loss studies do. Is the first thing we do the first thing it's just like really just science for for babies you know, like the first thing you look at for any type of study that says weight loss. How long was the study go wrong? It is a year 19 months stretch two years but then they have to stop it because then it's going to show them that the product doesn't work. And when I say I guarantee it's going to be a year 18 months because there is not once ever, ever ever ever been a study that shows that goes on for for five years or longer. That shows anything more than a tiny percentage of people were able to lose weight. It just doesn't exist it's just not possible. Okay, so seven people in the study receive quote rescue interventions that makes me so annoyed rescue interventions. What that means is two people got bariatric surgery and five got other weight loss drugs. Again, we don't know if their data was added or taken out from the final stats so we could have someone who's been taking we go V then had stomach amputation surgery lost lots of weight and they're like yeah just fucking put their this their stats in with the study because it makes it looks bad looks better. We don't know if they did that or if it didn't they didn't tell us I didn't so well that leads you to think it leads me to think that they probably put their you know their their outcomes

Unknown48:28

in with the rest of them

Speaker 148:31

there was a follow up paper printed in April 2022 Amazing exciting what we're going to find so this was a small study that followed 327 People from the original trial free year after they stopped taking the drug two thirds of the weight lost was regained surprise fucking surprise are you shocked oh my goodness I was so shocked when I read that the steepest rate of weight regain was from the people who lost the most and so you know if people are thinking well you know it I've taken it and it's great for me because I've lost loads of weight well this information or study shows that you're going to regain that weight at a steeper rate

Unknown49:27

this study

Speaker 149:30

quote from from Louise from all fired up

Unknown49:37

she's quote

Speaker 149:38

eat this study lead even gutter press Daily Mail to run a headline is fat loss drug we go V big farmers latest calm. I mean if right wing Daily Mail would run a story like that then the answer is yeah, yeah. Yes. So they made loads of claims that People were magically super healthy and that they sprouted wings and they had lasers coming from their eyeballs. So they claim to improve cardio metabolic health, testing the HB a one C, which is a diet diabetic measure. The change was from 5.7 pre study to 5.6. Post. Okay, that's a nought point one difference in a one C, right? So that if you know anything about diabetes, you will know that 5.7 is a healthy range. So those people went from healthy range to a nought point 1% difference, healthy range, cholesterol, triglycerides and inflammation markers went from a normal range to a normal range. They're hoping people don't look into this and they'll say, it makes people way healthier. It makes them you know, their Awan see is improved cholesterol, triglycerides, and from there all improved and so you would hear that and be like, cool, that sounds awesome. But it's this little like knee length like hey awaits them out, you know? Like, literally nothing to write home about late you would not look at that and say, Okay, we should say that everything that person is healthier because they went from being healthy to being healthy or normal range, you know, trial author Rachel Batterham said no other drug has come close to producing this level of weight loss Oh, my God, which is actually not true Fen Fen had a 16% weight loss which is more than we got a V. And it's a weird brag right weird rag Fen Fen was banned as it killed people.

Unknown52:14

Like, and it's not true.

Speaker 152:24

So basically, in a in a in a nutshell, this the studies show that people lose weight, about a pound let's let's be generous and say two pounds, two pounds a month, over 58 weeks around about best outcome. And then even if you keep taking the drug, you will begin to plateau and study has shown put weight on stop taking the drug. Within a year, two thirds of the weight has been regained. Also, also also in the study, many people were excluded people are not allowed to take part in the trials if they had diabetes, hypertension, a history of fibroid tumor, throw more throw more thyroid tumor risk factors pancreatitis if they were on medication, which impacted body size if they had had weight loss surgery, if they had used other weight loss drugs in the last three months if they had any history of depression or suicide attempt. So these drugs have been tested on a wide range of people, mostly white middle aged women. And so if you are not a white, middle aged woman, if you have any of these, if you have previously had weight loss surgery, had depression, had diabetes, etc, etc, etc, then this is an untested drug for you. Yeah, and as well mentioned for no information on trial design, recruitment or protocol. Every single person on the weego V trial was on novos payroll. So if you take it, you'll lose a little bit of weight. Stop taking it, you put the weight back on, even if you don't stop taking it, put the weight back on with horrific side effects, including risk of cancer. And what are those side effects look like? It's easy for me to say you know, diarrhea and sickness and lalala. We'll talk about that in the next episode, so I'm going to leave it here and then next episode we'll go into their marketing. We'll talk about the supply issues and celebrities will talk about people's personal stories. Tick tock what we do now, all of that type of stuff. So, again, If you enjoyed this information that we've I've presented so far and you appreciate the work that I do is providing you a free podcast. Go to the link in the show notes or you can find you can just google co fi feel forward slash fast fatty by me gone Biomek coffee or, or? I don't know. Subscribe Yeah, and we'll see you in the next episode while we go all over all of that other staff

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