4 Dr Kats on Peperine and Niacin 4

10:56AM Dec 14, 2021

Speakers:

Dr. Dmitry Kats Phd MPH

Keywords:

butyrate

pyruvate

gut microbial

piper

niacin

glycolysis

citric acid cycle

acetyl co

cells

species

deprived

happen

energy metabolism

colon

equilibrium

nutrients

supply

pathway

flow

gut

Their whole cellular respiration process through the mitochondria. Of this is kulana sites, this is in the colon here, like the micro microbial environment, this is their own life, this the single cell organisms, this is how they, I, if I'm not mistaken, I believe this is literally in their cell. Or in a way, it's they, I mean, these are small things, they, they are kind of part of our, I'd say, like, receptor, like the train of events forward. And they are they've, you it's like, it's similar to our citric acid cycle, but you know, what our pie. So it's, you see everything, so, so the butyrate, if once it goes, it gets deprived from it, none of that it's that gets more and more and more impeded, down activated, into essentially, then it's like, the end then the paper and the paper in is the whole goal of their whole from glycolysis. And on through the, through the, in these in this environment here, this whole map of see call it cellular respiration, here it is leading to like you look at where the citric acid cycle goes, it's like doesn't just magically disappearing the bits, it's keeping going. And like a dynamic flow of energy metabolism homeostasis, this is going on a steady state flow, ideally in a thermodynamic equilibrium. So once butyrate is deprived from from pyruvate, it said, so everything after pirate bay, then, so it's glycolysis into pyruvate. And then so everything after Pyrates so it's Acetyl Co A and on. So basically literally everything you see, outside of those first four, the glycolysis on the top left into pyruvate, everything after that is is completely goes to shit more and more and more and more, and the whole purpose of all of that of this whole thing going you starting from pyruvate getting to Acetyl Co A, which the gut, that's where the gut microbial species seem to introduce themselves now here is like after glycolysis, after glucose basically turns into pyruvate as it's entering the mitochondria, and about to turn into Acetyl Co A and then that comes you know that Claire Danes homeland you know, pet, you know, brilliant poster of these pathways, everything that happens then, and the whole reason this is happening in those cells, and that pyruvate turning to Acetyl Co A contingent on the butyrate supply, which the gut microbes, many gut microbial species, among other things, or exclusively make the breed rate to be able to, so that it can able to do this. And so, once that goes more and more and more and more, it's like everything else there ofter goes. And so, you see then everything else thereafter, though, and that whole, it's like that is favorable to allow butyrate to do that to allow the gut microbial species to make butyrate and, and for the whole purpose of everything you see there is to make Piper and that's their, that's their whole that's the whole purpose there's so that means thus then once that like that, Piper and continuing to go then is basically like a defining characteristic and any logical characteristic of essentially you know, lack essentially then, like lack of nutrient absorption, Mal nourishment, you know, fatigue, lack of nourishment of cells.

I mean, this gradually happens with this COVID Now, it can happen, it's happening, a hyper accelerated pace, okay, but and then it's with old people. You know, older people more at risk people, it's you see it happening more severely. And you see, and so this is something that is, you know what this is. Blossom is an understanding about what's going on in general. And so what it seems to come down to, like cause and effect, the story is that all that you see there is to make Piper in the whole gut microbial species environment, they're in their kulana sites, and the ability or colonic function, and the older gut axes, and the immune maintenance, and regulation and metabolic function regulation. And Melton, serotonin tryptophan, amino acids, every single one, pretty much everything that goes to every penny, you notice, you notice, niacin, I believe, does not go to the colon. It is bio it is synthesized in the colon through that pathway, you see by the gut microbial species. And that's where that's theirs, that's where the dysregulation is. And that's what they're reporting, and all the literature is based upon. So, so what's going on there is simply due to the butyrate having deprived and everything thereafter. And that's, you know, the whole purpose of this because now berates deprive was imminently going to happen. And the thing is, restoring the butyrate it seems to be you've saved in your restore the beater eight, there's a demand now. You know, everything that follows after, you know, to get you see how intricate that is. So now it's gonna, you know, the, the nutrients that it does absorb that our other cells need, that it's supposed to be like, alright, you know, I got enough here to do my stuff, I'm gonna send you off there, they're gonna absorb all of it, and or, you know, to try to get back and that's what you know, because they'll need like, say more, they'll need more riboflavin they'll need more time and they'll need more be six, they'll need more magnesium, they'll need more selenium, they'll need more koku 10 They'll need more vitamin E, vitamin A retinol, for sure. zinc, copper, they're going to need all that more. And also, it's not going to get in those cells more. I mean, it's they has to go. Many said with the niacin though, right? The thing with the niacin, though, is that it is not it's like there is a connection. This is what lastly needs to be teased out. So what happens right after what happens to this, Piper and right after that. And so what I think it does, the Piper and what it does, then is basically, um, it's, it's like the missing link, like the Ron De view or something, or, you know, like, like the, you know, a host to it, you know, it's basically like, it's what's made then to and, you know, we know it, it maximizes, you know, it promotes enhancement of bioavailability and byelection of nutrients, energy substrate. And so that's what's going to happen. And that's barely all that's going to happen unless you do niacin. And so the NYAS there's, there's a dis, it's through the TRPV one, and the GPR 109. A, as I think the GPR 109 Is the causal, but they're both they're energy metabolism, accountants in our bodies, and they seem to be, you know, they're not in equilibrium. And we're trying to we've been trying to do our best to, you know,

supply ourselves with the knowledge and understand we know, to feel better, you know, as good as possible. But we haven't this whole time, I knew that we needed to get this in into equilibrium. So I think the Piper and in some way I think it's three The epithelial lining I don't think I think that's TRPV one stuff is that the TRPV one is if you don't have enough Piper in or niacin going it seems like Piper and niacin are the