2 Dr Kats on Peperine and Niacin 2

Lone McCord1h 7min

Dr. Dmitry Kats Phd MPH

00:01

Right so um, league off I can't remember with it basically like the pirate the pirate Piper Cub, Damn these words Piper in if it's not being made see whether through the from butyrate becoming deprived and everything saved from butyrate from pyruvate to Acetyl Co A and through, up down left right in into and this so up down left, right so say through kind of those what I just said like from pyruvate into the citric acid cycle and there's these little side paths, right? You see that? Okay, I'm opening it now. I can't even open it. So, where's so you see this damn, okay. Alright, so the you see the pyruvate to Acetyl Co A, you see that? So there's butyrate right there. Shit. Eat decide. Is this recording? Yes. Okay, so you see the pyruvate? So, um, I believe so from the pyruvate. And now on, that's where the gut microbial species, the ones that we need to get screwed. Okay, so it's not even it feels like it's not even just about meeting this. The citric acid cycle in our end the humans energy requirements, but it's also meeting this look at where this pipeline is placed. Okay, so say everything's going right. And so we have the LS Veritate that comes, you know, from the weird thing right there from you know, the line from pyruvate to acetyl. Co A, and then says say, then we also have under that, the quinone. So, that's like clone ik acid, kind of, and so, that's B words A, right. So, you see those, so, so from there, and also a sorry, towards like the bottom ish, right, the two two Oxo glutamate into L glutamate, okay through the bottom bottom right of the citric acid cycle circle on the left side. So you see the L glutamate. And so, you see these lines like quinolinic has, there's like these like columns where that arrow from left to right intersects through, it's like a border I believe they're very important gut microbial species there that get drained. So the reason they're all draining it seems to say what's going on eventually is this if you see in the red the Piper in its stopping being made, once it stops being made everything before it or into an as it stops being made everything before it starting to be less made. But as it's then it's like, we just don't have the substrates to continue this or the flux. And that's again with the butyrate you see how important the butyrate is from the pyruvate to Acetyl Co A because if that doesn't have if you don't have enough butyrate the ALLAH spirit to bring a quinolinic won't be made. And the LRG I'm sorry, the L glutamine. I mean, it's so it's like they won't be made properly happening. It doesn't seem to be that direction. I think we might have and I know it's the treatment really doesn't I don't think it will matter and I'll get to that but what would let's assume that this is the fat like what would make sense and however it happens but the paper and stops being made. Okay? Once the paper and stops being made

Dr. Dmitry Kats Phd MPH

04:46

it's what's going to be happening then, is that we're going to need um, uh you know more nutrients and then testing then that's going to be you know, like, it's like we're going to be needing to make get more B vitamins more, eat more C more a more selenium, more magnesium, etc, etc. And so it's like it's at the same time. There's like these opportunistic past these alien gut species that make this that have this all happen, right? And of course there are nutrients that they need to answer so and say fibres that facilitate this, that the stuff you know, many, many things that are consumed that lead there, say melatonin also say tryptophan, say we would hope butyrate. But it's, it seems like this again, like they synthesize the butyrate. They synthesize all this short chain fatty acids from what we consume. They, they're good. They know that they they seem to set this up, okay, where you know, why action and or whatnot. But nonetheless, it seems wherever it is that the patron is, it's starting, it's, it's getting harder to make. And this is Deus, then the guts trying to it's so it's like, these, these speak the, you know, to for the opportunities to pathogens to try to get everything back to homeostasis, because that homeostasis also, this is their, you know, house, basically like their fortress. So they want it, they don't want this happening either, I would imagine. And so they're working hard to restore all this. And so what that's doing then, but they're just so Miss balanced in many departments. So deficient. That thick, you know, they're doing still backup napkins to do their best. That it seems like you know, what you would think that is like, oh, man, we just, we have to supplement all these specific nutrients and compounds that know, what you just need to do. So you see, like, say, you know, the pipe the pipe and gets used up, then it's like, it's that delta one pipe or region. It's, it's, there's less flux to it. And then you see, like two steps before that bond to the bottom left of it, the niacin then gets less used less biosynthesized every step before it gets less biosynthesized. And also, you know, and it's just there's every step before that gets less biosynthesized. Every step before that does to starting from the butyrate depletion. And then all these gut microbes are just trying to make butyrate to try to, it's basically everything that's going on that they're trying to do. It doesn't even it's like Look what their citric acid cycle is leading to. Do you got Do you see it? Like it's leading to, to, to fucking Piper? Piper? Oh, yeah. Damn words. But, I mean, there's they're all fuzzy but So, God. So yeah, you see what this is like the gut. This is the biosynthesis of alkaloids derived from Oh, yeah, sorry, I said or nothing, or nothing, or thyne, lysine and nicotinic acid. So these are amino acids. That I believe that. Like this is entering. It's like guts, these are very advanced, got species way more evolved than us. I believe they're using us. They're coexisting with us to protect them with our body system. They can't just go around and environment and get burnt up by the sun or stepped on by an animal or something. So So you see what's going on here though. So there are other you see there. It's like there's alkaloids to the clinimacs alkaloids. There's the Piper dine alkaloid. There's the tropane alkaloid. There's the Pinilla gene alkaloid. Yeah, but so it's theirs.

Dr. Dmitry Kats Phd MPH

09:48

They're all derived from or thing, Nick. It's Nate. Nice and and shoot Of course lysing so if you see though every single one they all merge there's all like a merging to dump off into basically piping no other ones are dependent on you know, it's like that they like say like a slide that you know three separate slides that go into the big pool to dump off the water club or does it amusement park water amusement park client you know that's kind of like they end up linking up here and it gets dumped off it's like all of this is part of a drive to make this pipe run and so as this drive gets less and less What's this is the this is why Piper and then you're seeing that it basically it every it maximizes the absorption and let's say bioactive bio availability of like the nutrients that we use because so it's there's what's probably going on is that if this if you had this gut dysbiosis this inflammation out the ass there is lack of immune you know this this immune dysregulation metabolic dysfunction there they're starting, okay. So if they if this if they're not making them Piper in, okay, this whole shirts, it's like our cells not making in a way it's like it's either ATP or na d plus it's almost like it's like that's there it's I feel like it's like it's like it's one of those two whatever it is, is the fact is it's not getting made and so this then whatever we consume, instead of like the normal amount and the gut microbial species being great and everything facilitating properly and then after you know it goes through our intestine if it gets there it's like there's going to be it seems a it's like everything we consume that is going to be like key things here right that reach the intestine are going to be like required and used up or or not process through. Like they're not it's like the not only it's like do they would they require more amounts and the rest of your bodies now not going to get it and that's where that's in this is what's it like your guts messed up and you can't absorb and disperse you know energy and nutrients to the rest of your body. And so it's because it's you know, there's going to be a greater demand is going to be less than disperse but also a high these nutrients like niacin, which they see in IBD patients is like a defining feature is that it's metabolite nicotine generic acid is it's it's like all of it is found in, in the in the stool of people with IBD. So what's going on there is it's like, the not it's like part of niacin getting to the rest of the body properly. Is is and that's what I'm trying to make sense of, but basically, like, what they're seeing is that it's I believe that what's going on is it's like not even you know, it's it's either like going to our intestine and not being moved through. Or you see this nicotine a, there's a metabolite of it, and it's like getting it's not getting absorbed.

Dr. Dmitry Kats Phd MPH

14:49

And now it's requiring it's like trying to absorb more nutrients to try to make that go right through there. Or there's other nutrients just they can't go through that out. And then move you know the assembly line and then move to the rest of your body. That's like where they say the curcumin or you should get a water soluble one will know that every curcumin, any curcumin, you ingest, it goes straight to your colon. The issue is that if your gut microbial species aren't balanced if what you're looking at right now this crazy, freakin you know, biosynthesis chart within the gut, if, if this isn't proper, the Curcumin is not then gonna, it's like the, it's like the gut species promoted like metabolize it, make it able to then go through liver and, and circulation reach all the rest of the body, and the signaling of how much to do. Like basically, it's like, it's impeded, because this is all it's like, the necessary steps through that this intricate process that has to happen as to continue happening dynamically. And it's and it's not. And, and also, it's like, you know, so it's like, basically, it's like the filter. It's like, it's not like your filters screwed and you can't now get what you need your oil into the engine to the rest of your body. I don't know if that's a good analogy, but it's that and also it's like these now it's perhaps then and that's the thing is like the guts don't they don't eat B vitamins. Well, they Yeah, they don't um essentially, they don't like they use them to make you know, products of what those B vitamins or minerals and nutrients are kind of substrates of are like receptor is essentially like receptor substrates enzyme substrates of the it's like they they're like the my Astro that moves it forward. And it's like it knows from our diet like okay, we're going to get this do that do that like everyday thing okay. Now all of a sudden you know what, once this goes to crap the whole it seems like thus the curative therapy the causal level therapy then now imagine this hypothesize this the pipe ring, right? What happens if you just give it Piper and and this is something that trips me out because how come they didn't know? And but how would they then know to tell us like the gut microbial species like say hey, you know you're humans you need to make more you need to ingest more Piper and like or maybe they didn't know and thought they're just like you know, this will never happen. If it does whatever we you know, we've lived long enough you know, or they just don't have control over it. Whatever the evolutionary biological explanation is, it is what it is but it's um and I'll get into that later on that for the for the treatment if you what if you just give them Piper now it seems like the so it's like the Piper and then is like essentially watch like so. It's like if the Piper in is provided okay there will there then be a need for all those things to happen? It seems like the pipeline is a link from the gut, back to the GI through that liver and into circulation and through us you know, all other alleys and axes, nerves, veins, etc. Of all the gut axes right?

Dr. Dmitry Kats Phd MPH

19:52

It seems like the Piper in is that's like that the Piper needs to be kept getting you know sufficiently biosynthesized through all this for then that link for you know that funnel to be proper to then get everything we consume that goes to the gut, or that say now isn't going to go to the gut as much because the species don't need it more to keep this this complicated, you know, energy metabolism into pipe, through TCA and to Piper and going so it's kind of like you just give the user it's like here Here you go. Like you don't need to do all this here's the paper and and so what that then does like you see curcumin then becoming bioavailable, you see vitamin A restored vitamin C, restored Vitamin E restored vitamin B six restore. I mean, what else iron restored, copper restored biotin seratonin tryptophan metabolism. That ability that's it basically, it's like, they're, they can now recover. Okay, they can they can reconstitute and do what the and then but the thing is also you got to get the inflammation out too. But so they can recover them and then it's like then it'll you know, it'll it'll deviate towards the trajectory becoming more homeostatic than this whole diagram from from freakin glycolysis down through TCA and the oldest son and then intermediate of that into all these all these owl owl Clyde's alkaloid sorry, and into Piper and so it's like it's like, it's this thing's, it's like in a feedback just rattled. And, and, and dysfunction dysregulated. But the way to this is what resets the gut microbial species composition. And, and then the butyrate. And then those cells to not feel or human cells do not fail is the it's like, give them a break. Let just given the damn pipe run, you know, administer the Piper. And at sufficient dose, they're, they're pretty much I think, like, prolifically safe, probably safer than anything else that's ever been in the protocol. And so, what then this does, and this is how you see that Piper, and then we see all the elbow results in the literature, the findings, you know, its main features is that it like maximizes bioavailability of nutrients and energy substrates. So that's, it's like, just give the paper in, and let the gut microbial chill and then they'll, it's, you know, they're freaking out, and they're dying and they're trying to do their, it's like, all of that they're trying to do that to make paper and when it can just be supplemented to it. And so once it's supplemented to it, then it's like, eventually pretty quickly. What will happen and then you hit it with niacin to what's going to happen then is nice is going to be able to get another cells every nutrient is going to be able to get another cells. The reason niacin didn't work as ideally as it did from day one, if you didn't, you know, supplement with sufficient niacin or if our diets had it since our conception and so now since if you get to a point where like, oh, like shoot, you know, now I have you know, 99/100 the ability to clear inflammation because I didn't do enough nice and right between that analogy PR 109 as like a fraction suppressed, then that's going to acute only grow them a niacin, you know it will it will slow it down, but inevitably you're going to die. Okay?

Dr. Dmitry Kats Phd MPH

24:38

But this is fine though, because and remember all these other nutrients, minerals, vitamins, they're very important too. But the niacin again is the king. You know they call it the the Piper ends the king of spices nice is the king But the ACE really but anyways, it's not getting that but that you get the if you then if you just basically this is through the GPR 109. A also these it seems like the Piper is, it's like the butyrate is. And I think what the GPR 109 name might be is around that the pyruvate to acetyl. Co A, I believe it's around there. And what I think the TRPV one is, is then it has something to do with it's like the Piper in itself is like an activator of it. In the sense that I mean, it's complicated, I'm, I'm speculating here, but it would make sense. It's like the Piper and we'll be able to, like, it's like an extra energy that is cents. And niacin provides a kind of like a potential energy instead of like a thermal, kinetic heat energy, it's more of know, like the opposite direction, like H plus. Nonetheless, and, um, and then the flush comes in. But what I'm saying like, what makes sense is that the pipe run, and I'm exhausted my apologies. But I want this recorded, because this is very, very intricate. And you have to have an imagination, but every This is what would make sense. It seems like this pipe is needing to be produced through all this intricacy of the glycols you know, the whole cellular respiration in this region with the gut. The once it's not getting biosynthesized properly, the gut species go to crap the you have the dysbiosis bacteria Kosis you have the permeability of the gut kind of even before that, with the inflammation then coming in because the butyrate with the Warburg effect, and then the pyruvate stops going down to the citric acid cycle. And so with that, then you know, the inflammation comes hits all these stuff, you know, and it's and now it's still, you know, it's still trying to make the butyrate to go down, it's still ultimately trying to make this piping. And so if we just deliver this pipe run, what will happen then is that quickly, eventually imminently and this can be in a snap, if we do I believe we can get a dose that can just completely safe dose that can do this in like a day or two with a few doses over the course of the two days and such. If we can do that, then it's the given enough paper in that it's like every, it's that's the uptake of all these other vitamins, minerals, nutrients, including niacin, it's not going to get impeded through this crap going on. It's not going to have to get used to try to make up for now, this you know, impedance of making Piper and of going out butyrate and keeping the citric acid cycle going before that and have you know, B vitamins or magnesium and selenium and also like you know, so like, also we were seeing love lysine was an inch, you know, like it would, you know, maybe lower your hospitalization time from what was like such a bullshit study, it was like 37 days to like 28. Okay, so, but that that's probably going slower. Where if you see that the from the LS period. See, it's like the lysines now not being made.

Dr. Dmitry Kats Phd MPH

29:40

So it's it but it's like it doesn't really do it's like it's the same thing kind of those again, are kind of sideways. The issues are and then like there's a lot of amino acids around here and they have a lot of interplay. But what goes on that if This shit gets rattled. What goes on then in, you know, whether it's the beauty rate. And I think it is, it's likely the, you know, like it has to, it's like, that's probably the first step likewise. And then, like, we're the beat rates, you know, having to work harder, and then it ultimately gets depleted deprived, and then there's got species are used up, and then everything from there gets, you know, reverse surround or goes into chaos, trying to make still Piper and, and, and continue the citric acid. So it's, you know, it's pretty much a really bad thing. And it and it snowball effects and the worse and worse. And, you know, you can supplement with a lot of these things or something, and just nice night feel a little better. Even say, like smoking, you see, like, even provide some nicotine, and the thing is, it's like, it's, it's, I'm not sure if it's like, can then could you just throw niacin in there, I'll do it. But what I am sure of is

Dr. Dmitry Kats Phd MPH

31:20

it's like the Piper in is almost I feel like it's like the ATP, the energy that the that it's like, ultimately the goal of these gut microbial species to be able to, you know, that's like the link the chain the link in the chain, that then allows the, you know, regulation, dispersion, and the metal, you know, the metabolic lights that are metabolized from what goes down through there, and then it gets dispersed the body, all that to happen. And then for the, you know, the if they're say, like some of the bees like, it's like, you know, they have to now they're gonna get used up in there, or, you know, it's like when I think more so is like, they're just not, they're like getting very slowly, very, they're depreciated in their biosynthesis on a massive, you know, accumulative forward rate. And this is like malnourished, malnutrition. And it's like, your body's just, it's, this is, you know, where we see the tryptophan oxidation depletion, the whole HR pathways, and they're where are we see, could quinolinic acid overload, because it's not going to niacin, we see a lysine defit being more depleted, because L aspirate, there's not like the gut microbial species, it's like, there's less and less because there's less and less butyrate. And then there's less and less of the species producing it. So that you see the more majority, you know, you see a shift in the, in the, in the distribution of the content of the composition of them, based on seeing more propio neat, and, or the acetate to, like, you know, less primary energy substrate mechanisms. And then say lactate to, and it's like, you know, it's the gut microbial species that if they make, it's like, whether they only make butyrate, or if butyrate is one of the things they make, those are the ones that get used up quickly, to try to recoup all this all ultimately, to try to make piping. Now, so what I believe is, that's like, it's like, it's, it's, it's not hard for them to make Piper and this is what they were evolved from or whatnot. I'm trying to figure that out. Well, exactly why that is. But so they didn't expect this to happen. And they, you know, it's like, I don't think they have, like, they have like board meetings or something. And they're like, no, like, Well, what happens worst case scenario, if this happens, and now, you know, we can't make the pipe room and continue the rest of the human body to function behave, be regulated, properly, dynamically forward, for us to be protected. In the gut here. It's you know, it's like a coexisting, but it's like we're really like their word. They're walking fortress in a sense, but now it's like, oh, shit, like their fortress. has been attacked. And it's getting to them. And now they're trying to do their best to you know recoup. And this is in not in us all not dying. And we suffer them. And so the quickest way to reset this whole, just like a chemical reaction, and it should be, like, from what's, you know, mirrored in the, you know, experimental investigations in the literature is that the Piper and basically like KYV pipe get, you give enough paper in every single thing that we, you know, ingest or that goes through our epithelium into there. And whether directly or indirectly through Interplay

Dr. Dmitry Kats Phd MPH

36:04

basically, it's like, then everything that we put in, is going to get bioavailable, we dispersed the rest of the body, because that's what was needed in the first place to allow that to happen in the first place was the was this whole chart, biosynthesis of alkaloids, this whole chart ended up in the through the glycolysis, the whole cellular respiration into the piping. That's it. So over life, we get more and more depleted of that. And that's how we get more and more depleted of nutrients and say with inflammation also, let's say obesity, where, you know, it's the nutrients aren't going aren't getting in there, and they're not getting into other cells that are obstructed. And so that's where then you know, we now we get a reuptake of all these nutrients right and there probably are like proper Central and systematic relaying and dispersion and reuptake and release and metabolism through into and through, you know, the intestines and the rest of the body from from the intestine there on and so the issue is sorry, my backtrack. So, like what we were trying earlier with, say, melatonin, you know, I've been the best I can do is based on the research people don't understand it. Now. I'm understanding it better. But it's like, oh, okay, so it's the melatonin what would it have gone? It's not gonna you know, the melatonin is you know, they've shown that it can restore the beat rate with like a genetically engineered fecal transplant I don't think we can do that unless we'll take maybe months with animals and then some butyrate but that's like the hard way of doing it like that was showing and this is with really low dose of the stupid bio Pierron and then with curcumin to I believe also that the curcumin at really high Joe's I believe there's a owlie where it can turn into a or like it leads to then Piper and Bing reinstituted. But it's at this it's like, it's not even curcumin, it's in there's no direct effects. It's this metabolites that you see them and I don't like a lot of the I'll tell you have Kurt if I can assure you if curcumin was everything they and I'm just ABCA one in the TRPV one antagonism or I'm sorry, the SRP one. inhibition is bad, the we don't need that and unless you want atherosclerosis to be my guess. Or the TRPV one antagonism we don't need that. So you know, I'm sure even it's had good results. But it's not you know, I think like it will promote the curcumin might promote because their gut species that kind of eat it, and it can promote and really help reinstitute Piper and if there's some evidence on this level of, of cascade and disruption. It's not going to happen and it's not and it's there's a better option. That's the paper, and it seems causal. So we supply the piping. And we can do this prophylactically to like to get ourselves to the level where all this is reset. So all their nutrients will go then to and then when we dose with niacin instead of it, getting you know, did you know trapped are not used up or used up too much or like not getting to the rest of our body and, and other nutrients to and their metabolites through. But it's but especially nice and that's going to help nice and to and I think we won't need as much nice and then it's like it's rarely going to go into all our other cells. And so in this way I'm still don't know exactly where the GPR 109 A and the TRPV one are, but I believe they're very around here.

Dr. Dmitry Kats Phd MPH

41:01

And what then happens is our our know, you know, human cells, the rest of our body that you know, depend on like this, they like vite like the B vitamins aren't vitamins for these three right here what you see with the gut species, or like magnesium and mineral and stuff, it's just the gut species are there this is a really distinct kind of pathway map here that that the species this is you know, unique to them this is how they do it, we're using what they have that gets through there. But there was so like, there's nutrients minerals, there, these are for our cells that we consume, but it just goes through this way and then so if this this maps messed up and dysregulated those the nutrients and and the energy we get from food is not going to reach us properly. And the most of most crucial importance is niacin. So once this is constituted again, the niacin then it's it's wave the wand and say that GPR 109 A is going to be reroutes then here this is going to lead then to nice like nice and readily going through GPR 109 a perky no contingent on whether the piping dose is enough that you meet the Piper and dose like let's say you guessed and it's like okay, wow you you hit it you need 200 milligrams with this say I don't know one environment not even need much mice now. See, like maybe only it could be like a lot of the flush was because we were going it's like we could we could have only used this much nice and to begin with based on the GPR 1098 expression like I was saying and the flush is like it's not necessarily the cheaper 1098 being activated and inducing that is just the the access niacin like whatever it is, is it and I'm almost there, but the GP it's there should be from the get go like lability now to where higher dose won't make you flush. And I think the SIR the whole flush also is that's it going away. It's not it's it's like niacin it's no I don't think that actually like so like niacin binding to this receptor doesn't induce the, it doesn't to the TRPV one. It's it's like it's physically making contact with with it with niacin with the tarp on from inside the cell after gets into cells. That's not like oh, you touched me. So I'm going to kinda like flip out. It's what happens is it's like this is now okay, I know not this much nice is in here. I'm gonna allow this much calcium to go in for and then. Now if it's, that doesn't continue, there's some kind of Hiccup and the flush happens or that there was and um, it's not a big deal right now. Like it's, you know, the flush, you'll see from the get go, I feel like if someone does turn milligrams Piper in with like a gram, niacin, a gram and a half, okay? Even that, like for the very first dose that could be 87 year old diabetic. Okay? i I'm like based on the mechanisms, which is in works to kind of conceptualize and share one's knowledge understanding of that's how intricate This shit is, but

Dr. Dmitry Kats Phd MPH

45:42

where there's going to be a level where it's like this, you, you know, give this much like where I was saying earlier like, you know, I wish we had an at home test that said take this much melatonin none that's gonna be with the piping and the niacin, but it's like you'll, what eventually will happen is you're going to get desensitized to, I think you can get desensitized to the flush. And essentially, that desensitization is basically it's like, you know, like urine in equilibrium, then it's not like a desensitization, where it's like, it's gonna get silence. No, it's just that that time it's getting less aroused. It's get, it's the TRPV ones kind of like a, like a tool that niacin and the Piper and can use, it's like, it's like it was made to sense niacin and Piper in as they bind to it, because that then indirectly paves the way like this, it's like it's signal for them calcium release, for then the calcium to make more and more, you know, and to zooms to lysosomes. And as this is happening, nice is getting into them more. And because as you know, at doses needed to where it's made enough, any d plus and now it's like, oh, it's because it's rate limiting enzyme is the is actually so yeah, this is What's brilliant about niacin. Two is that it's rate limiting enzyme is its first one, any PRT from nicotinic acid nicotinic acid model nucleotide. So basically you just made you know, just provide enough to where it limits it. And so that excess niacin then that's what I believe binds to then the TRPV one and what will happen then as a binds to it it's it's that whole like, See, the thing is the paper in it like the whole with the flush mechanism and the prostaglandins and the even the AraC arrived in accord acid. What else? coxswain caught tile six coffee, Cox to the N O 's, and no mine in Chicago outside. This all is dealt with, it seems, it seems like this is part of in a way, like a DNA over methylation. You know, like immune suppression, essentially GPR 109, a more and more loss of it. So another thing that might be is that the TRPV one is activated, based on based on the flush itself, and it's not GPR 109. A, it's the fact that it's like, it's like it happens after GPR 109. A, but this is part of what it's like this is what niacin does, and the downstream things of GPR 109. A, if Piper is not there, and saying this, and I'll connect to here soon, but the then the TRPV one, it's kind of like, they seem to be co receptors, the GPR went on, I named TR PVS, especially TRPV one, and so there's like a cross talk and interplay, where then it's like, once you have set you know, re modulate everything with enough pipe are nice and even from the get go. What you're then doing is like you're keeping contact trations levels that basically like any, it's like, they're gonna get heightened, it's like, if they get sensitive

Dr. Dmitry Kats Phd MPH

50:12

that you put it, it's not like you're gonna, you're not gonna ever go, like, ever, you know, it's not impossible to silence them completely, but you don't want to over suppress them either. But essentially, it's like, right now it's you basically, like re modulate yourself to where you're not just not flushing, but you're making sure all you know that there's no defense mechanisms with through the GPR 109. A, and but basically like that TRPV one is basically stain like, like, alright, just let me know, like, let me know, nice and like, or like you haven't, like, you know, you'd kind of do those three doses at the needed levels. That's an I'm going to write out you know, what I think for the kind of different scenarios and such and, you know, temporarily where, how to go about it forward and such. And it's, I think, again, no, this please I think we don't will not need it nearly as much nice to know. So yeah, I feel like it's like this is what's it's like the inch, it's like the intracellular niacin was like, it's stalling because there wasn't enough Piper in. To keep, it's like you would have to then throw more niacin in and but hope that goes through the GPR winter 90 properly. But it's like the the Piper and essentially will let the nice and directly go in as ever much needs to kill as ever many pathogens through the lysosomal formation in any DP, which is the only way to get any DEP to this level is niacin doing this. And you guys have seen my PowerPoint made little like cell chart, and it'll say like any and then there'll be any D like, then it gets into the app. It does the same thing in like no lysosomes. And then an extra nav plus from its, you know, the pop preschooler handler pathway that then it gets some tablets NTD n, a DP? There's that gets in through is that the CX? 40 330? Yeah, it gets into the CX 43. And then so nice and gets in no lysosomes. And I'm not sure what receptor that is that gets it in there. Maybe it's not one, but then it's like then it goes niacin, nicotinic acid, Myo nucleotide, and a D. And so what that is then is that any A D, and then from the CX 43 to any d p that got in, they do a two step base exchange reaction through the what is it the CD 38 enzyme. And so what that does is take any D and an A D, P, and makes an a DP. And so as this goes readily, right, this can happen. And so this is dependent nice and doing this is also dependent on pH inside the cell. And that's part of the signaling like the lower it is, the faster it's going to be going the and then and they're showing that the that the Piper, Piper Nate Piper in god damn so many compounds that the Piper in what's it called look like directly lowers the pH inside inside the cell for the signaling to go along properly. And it's kind of like the whole potential protons electron gradient between inside and outside the cell. And also the signaling of how like, Well, nice since like, if it's access, right? It's not being able to make those into lysosomes. The T cells aren't going they're not getting in the it's like the nice and dense like, you know what's going on? And I think that's part of the flush mechanism worked directly binds then.

Dr. Dmitry Kats Phd MPH

55:06

And so where it should might not be necessarily, but that it's like, what you what it feels this, like the heat, the thermo sensation, let's say, I don't think that's we're supposed to be I think it's like a lapse, because we didn't, we had too much nice and but usually its receptor wasn't a lot, you know, it's only so much nice and got used for what it really needed to do. The rest of it is basically like, like like a release of, like phospholipid Venom's kind of that if they weren't released, basically, like you would get cancer in a sense, or you would get septic shock in a sense, or thrombosis. Or, I mean, it's hard, it's, it's still very difficult to explain it's a, it seems like it's like a built up, kind of almost, about to happen, little cytokine storm that you can only treat it like you can only and this is like say the whole Vasso it's like a vassal constriction that you're trying to that it fights against. And it does the vasodilation. But again, and again, you don't want that and say like, a pepper making you hot. I don't think you want that. What you want. And again, this is like a fever response. It's like the inflammation, it's like, in a sense, like the that's the way to describe it. It's like kind of like the there's always inflammation getting signaled on it's like it's trapped. And you've got, it's like I can't let it out because you did nice, it's not going to be able to, to deal with it to fission kill it. Because this whole chain of this clock, this is mechanisms of the, you know, calcium and sodium channeling opening of these of these thermal regulatory channels. The niacin receptor, the cells flocks being prop, it's like basically, it's dis modulator, there's inflammation around. It's just it's like too much. And it's like, it's now it's, you know, it's like, like Dyson is essentially not abled, you're not able to do the things that you need to do for this nice and to do much. And then at the same time member within the gut, it's like the niacin is not even getting to the rest of the cells. So I guess take that with a grain of sand. But I just hope you understand how the level of the science but yeah, what my for all intents and purposes, it seems like you just give enough paper in, okay, this whole thing will go right. The Piper and also, I believe is a it's like a like, again, the these channels the most, you know, what we should focus on the most about the TR PB one channels I believe is here in the gut epithelium those where they're out there, and then how basically like they're sensitive as hell. And then there once they become one that's kind of like AES two or GPR went on in a way it's like you have a bunch of inflammation. It's like, Ah, I hope some more doesn't come and just mess me all up. And then once it does come then those those receptors, these two starts getting down really regulated into into silencing the, the GPR 109. He does as well on so that's basically

Dr. Dmitry Kats Phd MPH

59:59

Like, like you have to get things, things have to open. And this is kind of like the foundation here. This is the funnel, this is the like, this is really your brain here, for all intents like, this is what is this is the architect would say, the programmer, and, you know, the code set, it's just now it's like, the, you know, elements of the program are acknowledged, like missing dysregulated. And then everything that falls from there is and so what this is doing here is, like, essentially, it's allowing all nutrients to get back in to get and the gut microbial to start comfortably, like, get, like, put less stress on it, because now it's like you're giving them like, it's like you're saving their life like holy shit, you just gave us this damn Piper. And, like, what, but it's like, and maybe they've been trying to say like, GQ is the Piper and no, take some hope Dimitri finds it out soon. But yeah, though, you give it you you give you supply the Piper. And then everything should reregulate re modulate back with the TRPV one, what's going to happen is like you're going like, like, like your, these, you know, it should be like, pipe runs. It metabolizes out very quickly, it's half flights pretty quick. But if let's say like three hours, maybe it stays any. Nice and about the same, probably. So, you know, over the court, like three, like, you know, and I feel like it's like, we don't do that now. And it's not like, but like, we're getting go go in the hospital for COVID. But what I'm saying is this is beyond COVID we have exposure, all these external exposures that get into our body and that rattle our, you know, subsystem homeostasis, you know, our skins our own fortress barrier shield for our organs for, you know, our brain or heart everything. Our soul really, so, and this and then there's levels to that. And then, you know, it's like the Russian things the grandmas have with the, the Babouche, because I forget what the hell were you, it's like, you open the, it's like a little Indian in the Cupboard, low grandma looking red thing. And then you open the top, like, you split the body in half, and then there's another one within there, and then you open that one. So that's kind of like, the gut, then it's only like two layers. But yeah, once then, what this is going to be able to do is like, I don't think we'll need I think maybe a little boost in the beginning of some B vitamins. Of like, and that's the thing is you don't want to, like we do really do have enough from dye, I think, B vitamins we don't and, and likely the magnesium and like, you know, likely so many other ones. But it's like the reason that we don't but outside of the BS. The reason we don't have that from diet is is you know, it's like if we if this didn't happen to cumulatively over the life course the diets would be fine even with carbage foods I feel it but it's like stress of life and this you know, accumulating over life this inflammation into say the buret depletion and this you know, shit going to hell then and then the lack of dispersion of fee and this happens gradually and that's why we have you know, and that's why people supplement with everything they've heard is good. But so yeah, this is a very early am prompt to free had, you know me just orienting here walking around holding this damn button. So what this should do them, I believe, should be a curable I believe the proper the dosing that I feel like maybe a B complex. I don't even feel like we'll need vitamin A. I think like maybe the beef liver A B complex.

Dr. Dmitry Kats Phd MPH

01:04:56

And magnesium gluconate. I feel like down the road, we won't need those But to start off, you know, I wouldn't mess with that, like other stuff is not in your best interest, maybe a little bit of D, maybe a little bit of C, that's about it, okay. But the dose like I would do like, like, if you want to, you know, if you're not comfortable, it's new, I can assure you, you will be okay, no harm to. But it's like, again, it's like I don't feel like then we'll maybe in the beginning, we'll need to do a little higher of both kind of, to just make sure of the Piper and in the niacin, but I feel like you know, as things start clicking over, like you should, there should be a threshold of the dosing in like a day or two, even maybe on one dose that you can meet but maybe the kinetics there and you got to kind of move it along. But as soon as you start like it should be a quick where like you give these substrates to find the correct ones finally you will then you'll start quickly feeling better. And then it's like you won't need as much then accordingly but it's like the niacin now to like like I'm beginning to become more clear to me that like we don't want the flush actually. And the the sensitive like the whole TRPV one is kind of it's like the reason it's doing this thermo regulatory like that where you can manipulate with it and it's involved in this viral you know, uptake and tree you know, in replication and downstream segue and all that and I was feeling crap, is it's just because that that happens to be what happens rather than that, it's like something holy, that's controlling stuff. I don't know. I hope that makes sense. I'm gonna I'm gonna try to finalize this protocol now.

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