yeah, thank you guys for inviting me. So let me share my screen. Yeah, I hope you can see it. And so my talk will be about plasticity or wage, and how we can prevent attenuate and possibly even reverse age imposed diseases as a class, not one by one, which was not successful, but altogether. So primitive bill is speaking an antibiotic against aging, which you can see here is exactly what I see from my office at Berkeley is pretty nice courtyard. And unfortunately, I was not able to go there because of the pandemic for quite some time. So this slide is introduction into how we understand or rather do not understand the causes of aging. And you know that with chronological age increase, there is a dramatic increase in our organ deterioration and disease, which at some point becomes catastrophic. But interestingly, this chronological age is very different for mammals that are similar to each other in many parameters that we consider to affect aging. For example, rats live only three years and squirrels live 20 or 30. They are very long lived mammals. And even though that squirrels have similar size, and metabolic activity, in fact, if anything, squirrels have higher metabolic activity, higher metabolism, dendrites, they are mammals, and they have very similar diet. But yet, squirrels live 10 times longer. And so by the time the squirrel is three years old, it's a very healthy animal, but there are at three years old will be very sick, and really, really aged animal. And so TAs, first of all, it tells us that we do not really understand what controls the rate of mammalian species aging, we don't even know they have some theories. And secondly, that it is not simply the entropy or the rate of damage that controls because rats and squirrels really live in the same entropic environment. So, perhaps it is the capacity for repair. So, damage is something that we cannot change, but repair or efficiency or repair we can change. So here is another cartoon viewpoints on what a mansion See, if you look at the young person and an old person, the degree of damage will be the same. In fact, an old guy who takes care of himself or herself perhaps has less damage, if the half how to diet and wear sunscreen as compared to young people who may be basking in the sun and go clubbing every night and so forth. However, the rate of repair is significantly higher at at the young age. And so, perhaps, if we can improve repair an older individual, we can then rejuvenate them. So, this is kind of the general conceptual introduction to my talk, explaining what are we doing and why we believe that we cannot really chase down the entropy itself and reverse it that every single minute detail and to be perceived, but we can attenuated and offset that by improving render generation and that is the key to longevity. So I will speak a little bit about our experimental systems. You look at mesodermal rejuvenation and the dermal rejuvenation and ectodermal rejuvenate And those are the three germ layers from which our bodies are built. So we really start with messenger, mcdorman and the door, and then those differentiate into various organs and tissues. And so it is important if you look at multiple tissues in the nation as a class to make sure that all three germ layers become rejuvenate, for muscle for message on the look at muscle, and we'll look at fibrosis inflammation, poor regenerative responses, and we are able to show that old muscle for all practical purposes is to listen to young muscle, we're fibrosis and inflammation are decreased. And tissue repair after injury is not effective. Moreover, by the old tissue stem cells called satellite cells, and then for endoderm VRC, typically liver will also get fibrosis, adiposity and poor generation, and our experimental systems originate old liver turning it into young like, with fibrosis, the fibrosis and adiposity reduced, and the pathogenesis being increased. And then for up to dorm, the look at the brain, which is shared by many of our colleagues, everybody's interested in rejuvenation of the brain and cognition. Old brain is characterized by poor neurogenesis or formation of new neurons, increased neural inflammation, and also that leads to lack of cognitive capacity and memory. And be sure that our approach is now rejuvenate or brain making significantly younger such as the neurogenesis is improved. neuro inflammation is diminished, and cognitive capacity is enhanced. And I put 456, etc, because you pretty much now analyzed multiple hallmarks of aging and rejuvenation. So the axiom is that when several key organs become significantly younger than the entire animal will be also younger and healthier, and it will live longer. And I'm bringing this up because many people are asking, are asking me, did you do lifespan status or house further studies? And even though I will actually answer it, and we are on that path, you should realize that we are just the organ system composition. So if your muscle liver, brain bone immune system have become younger and healthier, by default, that means that you yourself are younger and healthier. And if you are younger and healthier, or the whole decline is no diminished, and how spawn is increased, you will live longer, there is no other way around it. Um, and then the opposite is not actually always true. So here is this image of very old supermodels. And living it is very old and sick, it is still alive. So it will be in a positive column. If people are just looking at the lifespan extension. So many lives, but extended animals are quite miserable.