This will happen if you take like one gram doses for decades. The whole purpose of melatonin is to tell niacin how much inflammation it needs to address. That's the whole purpose of it. If you're just throwing melatonin in your body, it's like being like, "Hey, niacin, where are you? Where are you?" And you're just gonna get tired and groggy. And yeah, if you do high doses, for decades, this could mess up because you're so 90. Every single drop of melatonin in your body, even the pineal gland is made biosynthesized and all the cells mitochondria, from tryptophan from the food and drinks we eat. What's what's released from the pineal gland has... Melatonin really has nothing to do with circadian rhythm. What's released from the pineal gland is like 5% of our melatonin supply. This is because we and it's happens when we sleep. And just which is usually at night and we wind down because we don't eat or drink when we're sleeping. So it we have photoreceptors that are kind of accounted to how much melatonin we likely used for antioxidation over each day, over each day, so that's what's released, kind of recoup it back at night because we don't eat or drink at night. Now, what you're doing with this protocol is over the life course. Melatonin is supposed to be continuing to tell niacin, "Hey, this is how much inflammation you have." But the problem is we don't have enough tryptophan or niacin in our diets and main most nutrients but mainly these two holy ones, to be able to to impede the over-accumulation of inflammation. So there'll be like, instead of five fifths melatonin for five fifths inflammation, eventually, over a few days.. decades, there'll be like three fifths melatonin, and that's only three fifths in the niacin receptor is being upregulated and that's only three fifths and then there's never even three fifths of niacin from diet. So even but even supplementing would make it so that you know you only get three fifths niacin in and that two fifths is the flush and the tingling is the actual niacin hitting the inside your capillaries. You don't want that. You want to get the full effect of the niacin and that's that's the whole purpose of melatonin is to keep the citric acid cycle going to make enough ADP which corresponding to how much ATP or inflammation or oxidative stress there is. So that amount of ADP is used then is part of the development of the expression of what they call the ACE two but it's really the GPR 109 A niacin receptor. And so that's the whole role of melatonin. So over the life course it's getting more and more stunning because this is we don't have enough from diet tryptophan to melatonin and niacin to dynamically continue to do anti oxidation and anti inflammation and keep us in a bioenergetic balance of eventually this inflammation over accumulates and it stunts receptors that are responsible for melatonin production from from tryptophan. And we never have enough niacin. So we this is how inflammation, aggregates and over accumulates. So what you're doing is essentially repleating. Thank God melatonin gets into our cells directly in the mitochondria, you're repleating the melatonin and hitting it with the niacin to get out this inflammation to to gradually not just restore your health and get pathogens inflammation, toxins, nanoparticles, whatever you can think of any foreign substances. You don't just rewire yourself to back to bioenergetic balance but you gradually restored then the receptors that were inflamed and damaged because of the inflammation and thus, you restore the natural melatonin supply. So what you're doing here is literally using up all the melatonin and niacin as the medicine to push out the inflammation and gunk that was impeding the melatonin progression, and then from from there, you're essentially like shining your shoes and putting a force field around it. You're just recouping reestablishing what our diets just simply don't have nearly enough of. It's completely organic. There's no worries with this.