Reverse Biological Aging & Enhance Your Longevity with Dr Chris Shade

11:34AM Dec 4, 2023

Speakers:

Angela Foster

Dr Chris Shade

Keywords:

npk

called

nad

cell

nrf

senescence cells

activate

ageing

compounds

glutathione

mercury

toxins

hormone

people

side

mitochondria

fasting

driving

longevity

resveratrol

glutathione is one of our central antioxidants. It's a central detox molecule. It's doing all kinds of heavy lifting around detox and free radical control. And as it's quenching free radicals, it becomes oxidised that needs to be reduced back into the reduced form. You're listening to the high performance health podcast helping you optimise your health performance and longevity. My name is Angela Foster, and I'm a former corporate lawyer and high performance health coach. Each week, I bring you cutting edge bio hacks, inspiring insights and high performance habits to unlock optimal health performance and longevity. So excited that you've chosen to join me today. Now let's dive in.

Hi, Friends, if you're like me, you're kind of like not I wouldn't say obsessed, right? But very interested, shall we say, in reversing biological age is something that I track on multiple markers pretty regularly just to see how I'm doing in terms of inflammation levels in terms of glucose control, different blood work, doing things like like an age testing, I'm now doing a methylation test to look at ageing. And it's such an interesting area, because I think you know, we have our chronological age. But then we also have our biological age. And it's fascinating, when you start to realise there's so much that you can do to stay kind of youthful and healthy. And we want to be extending our healthspan and our wellness, not just our lifespan. And that's why I'm so excited for today's episode because I am sitting down with Dr. Chris shade. And he is the founder of Quicksilver Scientific. And if you go onto their website, actually, you'll see the longevity wheel that we're talking about in this episode. And he breaks it down beautifully for you. We talk about NAD we talk about sirtuins talk about how to activate a NPK and an RF two we talked about the neuro endocrine system, we talked about how to use analytics, and also telomeres. So this is like a really great episode, if you want to know more about the mechanisms of ageing, and how much control you have over that process and the things you can start doing to really start living younger. So without further delay, let me introduce you now to Dr. Chris shade.

Hey, Chris, it's awesome to have you here. I'm so far I'm so happy that we finally got this sorted. I know we tried to meet up at the summer and at the summit, it couldn't make it happen. It's great to have you here albeit a few months later.

Few months and couple 1000 miles. But

that's true. I think it's my my early evening and your morning by differences. Yep. So it's good to see you. We were just talking offline, one of the things I'm most excited to talk to you about is the longevity wheel that you created. Because it's kind of often when I look at longevity and people's interest in that area and their expertise. They look at kind of or focus on one area like NAD optimization or something like that. Yours puts everything together in such a cool graphical way. That's that's, like not seeming that simple to understand. Because I know it's very in depth, but easy for people to look at at a glance and understand kind of how things fit together. How did you come about creating the longevity? Well, firstly,

good question. I don't really remember, you know, I think you start, you know, you're always whiteboarding stuff. And, you know, we have a lot of different products. And we're like, Okay, what do we need to fit in? And how do we talk about longevity. And so we just came up with this six pronged wheel that's bringing up the most important factors that you can affect with supplementation. And so like, we don't have stem cells on there, but you know, that definitely feeds into it, but what are the, the, the levers in the body that you can really work with, and so you see at the top, you know, just to like, lay out what it is. So at the top, there's NRF, two and a m PK. And some people don't know what those are, but m PK is what you hit when you fast and so if you're into longevity, fasting, carb restriction, water fasting, intermittent fasting, all those things activate a NPK, which is what you activate when you run out of food and that then mobilises fats and turn them into ketones, increases cardio metabolic efficiency, decreases insulin resistance, turns up insulin sensitivity, and really big for longevity. It activates autophagy to self eating. That's where you're going in and you're taking old parts of cells like say broken down mitochondria, Ill functioning mitochondria, or whole cells and breaking them down. You put them in this a lysosome you dissolve them back into their constituent points and you recycle their parts. So you get when you run out of food. Basically, you recycled proteins from your cells and you mobilise fat for energy. And that's really big for getting rid of old dying equipment inside of you. And it's very tied into the idea of senescence cells and breaking down senescence cells. Now, so that's a NPK and NRF. Two. So as you can see a sort of this biological detoxification, old burned out parts of you accumulated protein stores, it's called the unfolded protein response, old, old broken proteins. So that's cleaning you up inside. And then NRF. Two is more of a response to environmental triggers, like toxins, but it can also be a response to oxidative stress. So NRF two turns up all of your free radical control and detoxification machinery in the body. So you'd see how that's kind of core to keeping everything functioning, that's why it's the top one. So you go from there, then you go to NAD, which we'll talk about that a lot. You go down to sirtuins, from their telomeres are at the bottom, then you have senolytics are dealing with senescence cells, and then the neuro endocrine system. So all of these, you know, we can start to unpack all of these you see, these are all things that you can work on, you can take supplements for and they're all bringing up a younger version of your body. And in your operating systems, you've got a lot of different ways that the cells can express themselves. And it's based on resources that are available to the cell and the environment and the extracellular environment and the intracellular environment. So in a cell that's got a lot of toxins in it, the all these things kind of break down like toxicity lowers NAD levels, it damages mitochondria. And mitochondria are kind of at the centre of this whole wheel, everything's feeding into mitochondrial function. So when the toxins come in, they can cause telomere attrition that lower NAD levels that turns the turns you into a mitochondrial dysfunction. And that mitochondrial dysfunction leads into the cells being in a senescence state. If you look at the neuro endocrine, that the the damage to the mitochondria is going to stop neuro endocrine functioning, and sirtuins. So anytime you get all of these damage factors going in, and these toxin factors going in, everything's like on a knife age edge, and the body can go into it can go bad into this inflammatory cycle. Or it can go good into this inflammation control cycle. So on the good side, you have sirtuin activation, you're getting rid of senescence cells or reversing senescence cells. You have a healthy NAD levels in the body. And each of these they fit back and reinforce one another. And then you're controlling inflammation. You're bringing up longevity genes, the sirtuins the fox O's, and you're suppressing the inflammatory state called nuclear factor kappa B. So that's the sirtuin way, and then the other way. So we call that certs. And then the other way is sips. Those are I colloquially colloquially call them shitty inflammatory processes, but it's also stands for stress induced premature senescence. And that I said, when the toxins come in, and you kind of scribble all the good stuff, and you activate this pathway called nuclear factor kappa B, which then drives the cells into senescence, consumes and a D brings down NAD turns off, sirtuins shuts down NRF, two, and damages the neuro endocrine system. So the whole thing is about going this way, or this way. And then as you evaluate your supplements, you say, am I feeding all of these major parts of the wheel?

Interesting, which I want to dive into with you because I'm looking I'm looking at the wheel as I'm as I'm speaking to you. And there are very targeted therapies that you can use on each before we go into those. When you look at the way that people are ageing. And some people do seem to be ageing, even without sort of this supplementation, some people to be to be ageing more slowly, ostensibly, and they seem to have higher energy there are other people who you can kind of look at them right and they look like they're ageing faster. What do you think are the key things like if we if we don't want to age quickly, that we should be avoiding first of all?

Yeah, you know, obviously, genetics has a big thing to play on that but again, when you when you look at this, you know, are you over on this slow ageing, thriving side or this rapid ageing in you know, in inflammatory side, we call it in phlegm ageing. So what's going to tip the needle now, obviously your inputs if you're eating crappy food all the time, if you're really high on carbs called carbo toxicity, or glyco, toxicity, you're always going to move into yourself towards this inflammatory side, the toxins that you're exposed to all the time. Again, those can be from the food they can be, from the air you breathe when you're living in a city. In your buildings, if you have mouldy buildings or poor circulation, these are all just toxic drivers that are going to flip you over into inflammation. And then you know, when when once people are toxic and inflamed, they tend to get chronic infections, which also keep you over here on this side. So it's really about clean, keeping a clean environment around you getting great sleep. And there, that means controlling your environment, having the right amounts of light, not having blue lights, access blue light at night, being able to blackout curtains, and shutting down excess EMF exposure, Roger, I mean, often, you know, we're so worried about the water we drink, but we're not worried about how many wireless routers are in our bedroom, or you know how you know, the quality of the of the electricity coming through. And then, of course, you know, what's the quality of the air where you sleep. So these are just some some of the sort of basics to stay away from. And also, of course, getting regular movement and exercise. And that doesn't mean you're doing, you know, hit workouts every day of the week. But you do need to get up and move blood and do resistance training. So those are all just simple lifestyle things that keep you over on the good side.

Interesting, and I just want to pick up what you were saying there in relation to genetics, how much of it do you think is controlled? Obviously, we have the power to kind of put into place these lifestyle measures to positively influence our genes. But how much of that process in terms of how rapidly we age? Do you think we have control over?

You know, it's hard to put a number on it? Is it 50 5050 genetics and 50? You know, your environment? It may be I mean, some people just have such good genetics, they kind of over, overrun everything else, you know, they're like, Wow, I keep the basics in check. And, you know, I and I ate really well. And so maybe it's 60% cheese, but there is a lot that we can affect. I mean, the directions really are strongly affected by what you do. And, you know, we'll probably talk more about the genetic methylation tests like the two true age test. And that could be the absolute biological clock, like the Sinclair clock, sorry, the Horvath clock, or it could be the rate of ageing, the Dunedain pace. And the people who develop that, you know, they really found that people could have a very different rate at which they age, you know, they could double the rate of ageing on themselves pretty easily, or slow that way down. So you know, I don't know exactly, you know, what the, what the percent is, but there's a lot that you can control. Hello.

So when we left off the top of the wheel, because I think it's really interesting. So the AMQP K and NRF two pathway, there's a number of compounds there that move the needle, and some of these are featured in other areas as well. And this is really about regulating autophagy, and metabolic health. Can you explain some of these like lipoic acid and Berberine? Like here? I'm thinking about, you know, blood glucose control, for example, but you've also got dim and corseted. And can you explain the key things here? Because it's really interesting, and would you advise that people were supplementing with all of the compounds? Or would it be looking at testing like different areas where they may need support?

Yeah, you know, if you look at like our product line, we have there's these two sort of like Brother, brother products one's called liver sauce, one's called NPK charge. The NPK charge also used to be called keto before six. It was his play off a book called Vegan before six where you eat plant based all day and then have animal based at night. And in that NPK charge or keto before six. If you have that in the morning fasted, you'll go right into ketosis, you'll be able to measure ketones right in your blood, unless you're really cardio metabolically unfit might take a couple of doses to do that. But most people one dose boom, you're making ketones, and then at night, you're gonna have carbs again, then the next day, so go back in and make some ketones. And there's that and then the liver sauce is more. And so that's about activating NPK and getting into autophagy and ketosis. The liver sauce is more about activating NRF two, which is that energy detoxification. And there's a couple of compounds that are in both like worse than does both enter have to up regulate or edit and BK activator. And it turns out, most things have some or both that are in that category. And they're just a little harder on this one versus that one, like, like block s is great enter of to a regulator. It's also an NPK activator question is about equal on both sides. Berberine is a little bit of NRF, two, but more NPK. And so there's a lot of overlap both both products have silymarin and Corsten. And dim in them, because they both to both, but then the NPK charts has Berberine and resveratrol and cinnamon, which are strong, and began activators. And on the other side, you know, the liver salts, we have more things that are aimed at at bioflow. Because detoxification has to be coupled to bio flow. And so it kind of depends what you want to do. You don't have to do all of them. But you know, and I also like people to sort of cycle between things. And one of the errors that people make, and I was doing a webinar with Mindy Pels. Last night she was talking about women fasting, and what they'll do wrong is they'll start on some sort of fasting protocol, you know, I'll you know, I'll fast 16 hours a day, and then work well for him at first, but then they just stay on that, and then it starts stops working well and it starts working against them. Because we do need to cycle you don't just do something all the time. And this is a biohack error that people often do is just do the same thing all the time, because they heard that it helped, you know, we need to cycle some of these things. So yeah, you have all these different compounds. And they all you know a lot of them are NPK activators, some are gonna have to activators some of these are also then sirtuin activators and like resten kind of does all of these different things like Corsten can help turn mitochondrial biogenesis up through this mechanism called PGC. One alpha, which is a sirtuin based mechanism. And as a sirtuin based mechanism. It also needs NAD. So as we start unpacking and going through these, we'll see there's a lot of interrelationship between them.

And NAD when we're looking at that, and ad one stunning is this kind of halves every is it every 20 years. So it's kind of starts to really, you've got like vastly reduced, right, I'm approaching I'm 47. So coming up towards 50. My levels will be kind of vastly reduced. Now compared to my 20s. It

might be a little overstated, that it cuts it down, but it's definitely going down. Okay, okay, yeah. Because, yeah, something that goes down with age and one of the reasons is you start consuming it a lot. And so when we think about NAD, we got to think about why it's going down. And you know, age brings a lot of things down, but one of the reasons that really drive the NAD consumption are inflammatory processes, and one of them is a gene damage thing. So as we accumulate damage to the genes, these things called parts get upregulated because they're, you know, desperately trying to keep you from creating tumours. And so they start consuming all of this NAD to keep your your genes repaired. Another one is called CD 38. And when, remember, I said there's this sirtuin way or this inflammatory way, once you get into that inflammatory path, nuclear factor kappa B gets activated, which is a chronic inflammatory pathway. And that activates the CD 30 eights. And they're trying to repair things and they don't always know why it's kind of reckless, and they consume NAD. So NAD is being sucked down by damage to the system. And then we need you know, when you're young, you can make NAD very easily from any vitamin d3. Remember, NAD is in the content of mind add nine dinucleotide like nicotinic acid or nicotinamide this are precursors for it. And then when we get older, it's harder to recycle our NAD and it's harder to make it from simple vitamin d3. So we start using these advanced precursors nicotinamide mononucleotide and Imen or nicotinamide riboside. And our

and when I look at like for example, like Dr. David Sinclair, for example, how much a man he would be taking things like that, it seems like quite big amounts. How much do we need to take ready to optimise?

So we do it a liposomal. So we get about fourfold the, the absorption of four to five fold the absorption of when you just taken in a powder and might actually be more it's really hard to measure NAD NAD metabolism in the body. It's very difficult to try back, but, you know, for me, you know, I do about 100 milligrammes a day in the liposomal form say that's 400 milligrammes. So I think you know, somewhere around three to 400 milligrammes a day of one of the precursors tends to be enough, I think Sinclair takes a full gramme, it gets a little bit pricey, and maybe it's a little more than eight. But you know, if you can afford to take a little more, I don't see why not. The one thing that people miss though, is balancing it with methylation is as you're driving, and a the mid cycle once you make an ad, and ad activates a sirtuins, I'm sort of making the circle up here, so you're an ad up there, you activate a sirtuin, you're then turned to nicotine of mind, which is sort of the spent an ad and then you have something called the recycling pathway. That takes it back up to mmm, and then at a man goes to an A D. Now that path from nicotine amide to Mn is driven by nampt. It's an enzyme that one gets down gets turned down by inflammation. So these, the same ageing process makes that weaker and weaker. So ageing is consuming NAD and limiting your ability to recycle NAD. And so then you've got this nicotine of mind, and you're not able to get it back up the hill. And the problem then is that the nicotinamide itself is inhibiting the sirtuin activation. It gets stuck on the activated sirtuins. So you need to sweep it away. And you do that by methylating it and then paying it out as methyl nicotinate amide. And so how do you methyl it it's an enzyme that donates the methyl group from Sam e s adenostoma. theanine. So Sammy is your universal methylation donor in your body, it's super important. When it goes low, you've got depression issues, you got mitochondrial issues, and you're consuming it and when you consume it, you generate s adenosine homocysteine, which then becomes homocysteine. homocysteine then is a pro inflammatory cardio toxin. And so right as long as you're bringing it back to my theanine, so you've got a cycle called the methane cycle where you bring it back to the thymine, and that interacts with also the methyl folate cycle folate cycle, the MTHFR driving that over. So you need adequate methyl donors from trimethyl glycine from methyl b 12, you need the catalytic effect of B two on MTHFR. You need some benign in there, when that's all running, then that's fine. So when you're driving precursors to NAD in, you also have to drive in methyl groups to be able to get rid of the spin and a D. As long as you're doing both of those, you can go up to a high level of dosing. But like I said, you know, these lowered couple 100 milligramme doses of the precursors tend to be enough.

So if you were driving that process, right, and that recycling, you're helping that which is the salvage pathway, right? But you're not taking account of giving the methyl donors sufficiently, then could you then end up with a problem? So if people are taking kind of NAD precursors, but they're not now they're folate deficient, for example, they don't have enough trimethyl glycine, and things like that, could that then cause a problem

effectively? Yeah, it's gonna drive even more methylation deficiency, hypo methylation, and, you know, you're hoping that NAD is gonna light up your brain. But if you're deficient, all these B vitamins, you're gonna have a problem there. And in fact, there was one guy who was a friend of mine, he was taking an event. And I noticed that he was, like, phasing it a little bit, neurologically, he was like, Whoa, and, and I caught him in it. And I'm like, if you've been doing he's like, yeah, that's been happening recently. And I was like, here, you need more methyl donors. And we, we gave him more of our metal charge, and just fixed it right like that. And, you know, in his family, you know, they've, they're predisposed to Parkinson's and different neurodegenerative things. And so you need a lot of methyl methyl groups for those people. And the more on your stress you are, the more methyl groups you generally need. And so that's something you know, we're taking the NAD to, you know, increase our performance, we got to make sure that the methyl groups are there, you can actually hurt yourself.

Oh, yes, super, super interesting. Thank you for clarifying that.

I mean, most of the real smart people now picked onto this because I've been beating that drum for it's I didn't discover that but I've been beating the drum on that pretty hard. And so a lot of people are putting TMG in their, in their NAD infusions, or they're making them taken other different ways. And so that that word is getting out there. Which is good? Yeah, really good

70 Something it and the sirtuins then we come to the next part here. And again, some of these overlap, right. So when we were looking at a NPK, for example, resveratrol, and quercetin, how do we activate these? The sirtuins? And is that the supplements that you or the composite you've got here? Are they all in a blank? Is it something a case of like taking these or because sometimes we hear of people picking them off, right? I'm taking pterostilbene and things like that. I'm just curious. Yeah.

So you look like our NPK charge, you know, today, the activator, talk to us or do an activator. I often say what's begun with AMP, BK is codified in the system was sirtuins. So the amp BK is like, Oh, we got to start doing stuff here. And then you start when you start activating sirtuins, they kind of encoded into the system and create more longevity to those pathways. So what do you need to activate a sirtuin? Now we think about stacks sirtuin activated compounds, Tara stilbene, resveratrol, question is one, Curcumin is one. And they the sirtuin protein has these different docking areas in it. One is for NAD and the another another one takes these different plant compounds that are sirtuin activators so first you need an ID to activate it and then resveratrol, of course then go in and hyper activate it so you have a highly activated sirtuin. It's funny you know we have we have two different products. One's called NPK charge. Another one is now I even forgot the name of it. It's in a capsule and it's called the ship to an activator. It's almost exactly the same product. It's just people need these cues that Oh, this one's first sirtuins and you don't need to NPK is better to stack a couple of different ones that should tune activation, maybe not as important. It's okay. You know, like what the Sinclair do. He does no man and Anna man and resveratrol. Now guarentee, who was one of his advisors when he was in grad school, he does and are and are still being, you know, because he's aligned with Chrome and x and they sell those products. And then Sinclair is making his own pharmaceutical company to, to sell Mmm. And he's actually kind of screwed all of us in the supplement world because he's gotten the edit. He's gotten the FDA, despite approving all the applications for mn as a supplement. They now said no, you can't use that Amanda was a drug already. We just didn't realise it was a drug and Sinclair has this company. And now you have to stop selling animate. That's just a little side political note there. But again, sirtuins need an ad to activate them and then they can have this extra serotonin activator act on them. Remember though, if the nicotine amide builds up, then that blocks him so you need the methyl groups to free up the sirtuin activity then you need the NAD then you can have the sirtuin activated compound. Now, one of the reasons why there's conflicting data around resveratrol and some of the data said resveratrol was making the people works. Because if you jam in a tonne of resveratrol, you will force the sirtuins to activate and they will draw NAD out of the mitochondrial pool to activate the sirtuin and you'll end up with an ad deficient mitochondria. And you'll generate mitochondrial dysfunction. Whereas if there was enough NAD and you're throwing the resveratrol, you actually generate more mitochondria, mitochondrial biogenesis needs NAD Institute and activators with it for that to happen. So sirtuin activation is great thing, but you got to make sure that your NAD pool is intact when you really go after that path. And when we've when we've looked at using these compounds in these nanoemulsion formats, and we looked at activation of the sirtuins and white blood cells, we saw a single dose of these compounds was able to create a better threefold two to three fold increase in sirtuin activation. And that 24 hours after the dose it was still activated. So you know these are these are potent molecules for getting sirtuins up in the system.

Yeah, so it'd be risky then to take something like resveratrol without optimising for NAD.

Yeah, yeah, if you know and that would be like a case where some of these older and maybe cardio metabolically unfit and you're trying this one hit wonder thing. We're gonna fix you with resveratrol, you may break them

As we close out 2023, it is a great time for reflection and also for planning your 2024. And one of the key areas to achieving any goals in life is health. It really is the foundation and the bedrock of all success. And the first thing really is to address what your health looks like right now, in terms of the key areas, and to start with what I call the domino. And the domino effect really is the one thing that you can start implementing straightaway, that makes everything else easier. So for some people that would be sleep. For other people, it will be eating a healthier diet or managing their blood sugar. For others, it could be getting into a workout regimen, we know that people who work out tend to eat better for the rest of the day. If they're working out. For example, in the morning, there will be that domino for you. But the first thing to do is to get a snapshot of where you're at. And we can help you do that with our biohacking quiz. If you head over to your total health check.com, you can take a 60 seconds quiz, and we will score you on each area of sleep hormones and HRV insights you're tracking how you're fueling your body and mind and how you're training your body and mind. And we will send you a personalised report complete with recommendations on how to improve, we'll also offer you a free call with one of my coaches to go through your report and find out what that domino is for you. So you can start implementing measures ahead of 2024. And get yourself into the best shape and vitality to achieve your goals next year. If you want to get that snapshot of where you are right now with a free personalised report and a call to help you find your Domino, head over to your total health check.com. That's your total health check.com. And then we move on to telomeres. Which is interesting. So I don't know if you briefly explain I always hear it explained as being like these or as compared to shoe laces and the tips here. You've

got Yeah, the tips of the shoe laces are the tips of the chromosome. And they serve this protective mechanism for the chromosome. But it's a little bit more mystical than we even acknowledge. So as these tips shorten, there's a lot there's a degradation of the integrity of the genome. And and you start to think about it and you're like, well, they must protect on the end. And it must be these genes right near the end that gets sort of frayed and they don't work right? Well, the gene that's not working well, because of the shortened telomeres maybe all the way inside here. So it's almost, you know, it's like a holographic view of the light field of DNA, and the caps are keeping the integrity of the hologram. And when the caps are whittling away, the hologram gets dysfunctional and it can't project, the image of the healthy cell, the healthy being. And what happens then it's called telomere attrition, and certain Thompsons do it very, very well. Then the cell moves into a senescent pattern, it does that through a mitochondrial mechanism, the mitochondria get dysfunctional, and they start releasing proinflammatory cytokines, and the cell goes into a cell cycle arrest where it stops propagating. And it just sits there. And this zombie like state now we say zombie like because it can bite the cell next to it and turn it into a zombie. How's it bite? Well, it releases the cytokines that are pro inflammatory, and they're spreading out and infecting other cells, other cells can carry that signal to go into senescence as well. And so it's a propagating field of degradative inflammation. And these inflammatory cytokines are the ones that start consuming NAD and shifting you into this inflammatory downward spiral state. And so we need to, you know, there's a lot of different theories on how do we deal with the telomeres. Now, one, you got to protect them. That means having a MPa and enter have to active so that you can, you can break down bad mitochondria and get them out of the system. So you can intercept the toxins coming in before they create telomere attrition. And then there's an enzyme called telomerase that is trying to maintain their length and so you need that active. Now, that is much, you know, there is a supplement called ta 65. That's supposed to speed that up, but it's a pretty negligible effect. It's hard to take something that really changes that activity, except for the peptide, EPA talent that is shown to to change telomere sighs All right. So the other thing that maintains telomerase working is having a lot of glutathione in the reduced phase. So glutathione is one of our central antioxidants. It's a central detox molecule, it's, you know, doing all kinds of heavy lifting around detox and free radical control. And as it's quenching free radicals, it becomes oxidised that needs to be reduced back into the reduced form. And enter have to is, well, it's reduced by something called glutathione, reductase. And glutathione reductase puts electrons back on the oxidised glutathione that it gets from NAD SR molecule NADPH. So now we see this overlap between NAD pools and the reductant NADPH. And its ability to keep an glutathione in the reduced state. And then the reduced glutathione is keeping the telomerase active. So all these things are overlapping. So keeping glutathione levels up keeping NRF two active, which helps you make more glutathione reductase, and helps you make more glutathione is helping protect the telomeres interesting.

And when you're looking at like the like inflammation comes up, obviously time and again here. If we wanted to test levels of inflammation within our body for these purposes, there are so many ways that you could look at this in terms of inflammatory markers, what are the key markers we should be looking at, we

don't have a lot of good inflammatory markers, you know, CRP is one. But once therapies, there's some chronic infection you're fighting. It's not as much about, you know, this, like if we had better measures of like NF kappa B. And you know, there's a lot of people trying to get these into more commercial availability is all the different inflammatory markers. One way is to look at subsets of your white blood cells. And so those tests are starting to come around. But there's not not a great 1.2 right now. But it will eventually be measuring low levels of different laboratory cytokines. And looking at the grouping of all these different inflammatory cytokines and how high they are. And

you know, that I know if you come across the test, the glycans test by a company called glycan age, they seem to, like the immune system. Yeah.

And that's, yeah, that's inflammatory damage. That might be a good way to do it. I just haven't looked at those tests much. Yeah. Okay.

Okay, and then we move into some analytics that helped to manage the presence of senescence cells. Yeah. Do you want to explain for people that have never heard what a senescence cell is?

Well, it's gonna Yeah, so that's, well, that's what I was just describing as the zombie cells. So you know, and that path most describing is one of damaging the telomeres, and the cell flipping into the senescent pattern. So the senescent pattern doesn't grow anymore. There's what's called the senescence associated secretory, phenotype SASP. That's when it goes into this state where it's secreting pro inflammatory cytokines and not growing, and so it becomes a source of inflammation in the body there. And so, if you imagine that the senescence cell is near, you know, like fibroblasts say it's a senescent fibroblasts, then it's not going to make collagen anymore. So you look at you know, wrinkly people, there's senescence cells down there that are no longer making collagen and elastin. And so we want to get rid of these cells. And so there's something called a central lytic lytic. Their licence means cut. So there, you're going to stimulate a profit, you have the whole cell, and you're gonna break down the senescence cells. That's sort of at the higher doses. This happens when you get like a nice peak of these compounds that are senolytics like Weston. Weston is like the Swiss Army knife of ageing, and PK. It's NRF. Two, it's sirtuins. And it's it's analytic. So we can do a lot of different things for you. The fysik tin is one that people use, it's a lot like Weston luteolin also works as one, resveratrol and curcumin, a lot of these compounds that are doing other things when they're at a high dose in there, they help stimulate your destruction of senescence cells, but we can also move the cell back out of senescence, especially if it's early on, and it's just gone into the senescent phenotype, you can pull it back out by restoring the redox potential of the cell which means up regulating enough to restoring the glutathione levels, having the NADPH levels up there, and the cell can pull back out into a normally propagating sea. phenotype, so you're either going to cut it out of there, or rescue it. And so some people will do to do real high doses, you know, just a couple of times a month of, of things like Corsten. And Feist in the SAT nib is a is a sort of a pharmaceutical that does it. And the key is that you have to get a high dose into the blood. And that's where these nanoparticle deliveries like the nanoemulsions that we use in the NPK charge or in the liver sauce, they are able to get these nice high peaks into the cell, we did a little bit of testing around that you see, there's actually a peak of there's something called beta beta collecting. Now I forget the the name of it, but it's one of the things that are made when the cell senescence, but you also peak them in the blood, when you break down a bunch of senescence cells when you get the doses that you need for to be acetylate. It can, you know, we've seen that surge of those, after people taking doses of these nano emulsified forms, of course, and luteolin resveratrol.

And that will be a couple of times a month, you're saying as opposed to and yeah,

I mean, some people do it that way. But they'll take like, you know, like 10 capsules or something to get. You know, I think that when we're doing it, a lot of you know, in my world would take a lot of the NPK. And I think we're you know, maintaining the senescent cells that are pretty low level by doing that on

an ongoing basis. Okay. And when you were talking that was really interesting when you're talking about like collagen, for example, and elastin and the cells if this person and people are getting wrinkles. So in that situation, then someone could be trying to do everything they possibly can right to optimise for college, and even taking these vitamin C, or they may be taking collagen, and hoping is going to have benefits. But actually, if they haven't fixed this issue, then they're not going to see any reversal and wrinkling for example.

Yeah, I mean, once once that, you know that senescent pattern has made its way down to stem cells and fibroblasts and things that regenerate, then yeah, there's, you know, the machinery is dead in there. And you can take all this stuff, and it's not gonna fix it. And, you know, that's why fasting is so freakin good. Because fasting stimulates all of this stuff and fasting, reboots, the immune system and reboots, all kinds of stuff. And, you know, often we just have to do you know, we, we want to be able to reverse everything without changing our diet without doing something like fasting. But you need to do that, you know, even if it's just the intermittent fasting where, you know, you're maybe only having one meal a day, and you're carb restricting it that that's how you can really turn up these processes well.

Okay.

I'm going to share a little bit from Mindy Pels webinar that she did with us last night, she wrote the book fast like a girl. And she figured it all out that it's just with your hormones cycle in a monthly hormone cycle. When when you have your period, you start your cycle, that's when women should be fasting. Because really the hormone that needs the food and it needs the specialty, the carbs, that hormone is progesterone, which is high in the second half of the cycle and low in the first half. You know, the oestrogen peaks need some too, but it's really that progesterone cycle. So you know, the first week to 10 days of your cycle is when you should be fasting more as well as a woman. And you know, there's one other window in there right after you ovulate, where he confess a little bit more to but most of that fertile side of the cycle needs some blood sugar level and some level of carbs to support the progesterone levels. Yeah,

I've had Mindy to come and talk about it on the show, actually. Yeah. Okay. Really awesome. Yeah. Love, Mindy. And do you think like, with with women who exercise and I guess that would be my question, right? Because exercise is a good lever for autophagy. What are your thoughts there? Because for women, for example, who are very lean and athletic and they don't have any weight to lose, they've got good muscle mass, and they need to be supporting that. Would you then still encourage fasting if they've got a high volume of exercise? No,

I think you're getting a lot done there. In especially if you take some of these compounds, while you're, you know, before the workout, you'll get a very strong response in NPK. And you'll be able to get all the processes happening. It's you know, the lean wants it just there's there's a fine line between some of these fit works out and then the over trainer, you know, so these triathletes and stuff, most of them their whole reproductive set is shut down and it there's sort of an irony there's a lot of fit people that have fatty and filtration even in their liver because they take so many carbs for all those workout those gels and stuff in the sugar all the time is blocking some of that. So, it there's there's sort of a fine line where you're trying to carb restrict enough to get the autophagy. And with that is a lipid ology which is burning out the fatty intrusions. But you don't want to starve out the system.

Yeah, for sure. What will be the key compounds to take pre exercise? I'm interested because I'm kind of big on exercise daily. So yeah,

so those NPK activators, especially if you if you do some of your workout fasted? Yeah. You do. Yeah. First thing fasted any of those things in NPK charts, the Berberine question resveratrol, you will generate high amounts of ketones. And that's good. I mean, I'm really of the mind that we don't have to be in ketosis all the time. But we need to generate ketones some period during the day. And if you take like ampere a charge and go workout, you will, you know, your ketones will be, you know, point A one millimolar in the blood. And then you can go and you can eat whatever you want for the for the rest of the day, because you'll have this flush of ketones, you'll have a flush of autophagy. And any of the processes that go with Ampy activation. Yeah. The precursor before that, and then you'll get all the sirtuin mitochondrial biogenesis. You get the whole game.

Yeah. Do you NAD precursors before? Yeah. So then I just add the NPK. Interesting. Okay, so last bit in this really excited by this is fascinating. I could talk to you all evening. The neuro endocrine is the last piece here. Yeah. And a hassle.

Yeah, and you know, so we're talking about neurotransmitter generation, we're, of course, you're talking about the whole hormone system. And the whole hormone system is really regulating power in the body and the body morphology more than anything else is. And there's a high energy consumption for these glands to make these hormones and the neurotransmitters and you know, nothing controls your brain space, like your neurotransmitters. And so they're very mitochondrial heavy. And they're easy to damage that whole system through having mitochondrial damage, but think of all the toxins that are endocrine disrupters, these different Xeno estrogens things like plasticizers and such that are getting in and activating hormone cascades or blocking hormone receptors. So how do we work on all this? Well, we have to be detoxifying regularly. We need to keep bile flow going we use a lot of bitters for bile flow, that keeps you detoxifying, keeps you moving toxins away from the hormone receptors. So you know, you'll hear when I talk about hormones, I talked about receptors as much as I talked about the generation that hormones because like Andrew genericity, in a male is a function of the testosterone level and other antigens, but we'll just focus on testosterone and the density of androgen receptors, just like there's mitochondrial density, there's not a fixed number of mitochondria in the cell, we can make a more mitochondrially dense cell. There's also not a fixed number of hormone receptors, we can make higher density to the hormone receptors, and the compounds that do that increase the density of the receptors, and also increase the fluidity of the receptors their ability to to trans to take that signal and and effect that into transcription in the genes. The compounds that you use for that are adaptogens. So adaptogens would be like ashwagandha ginseng, a stragglers, and these have compounds in them that all end with IDE s their eyes. So Jin Sena sides, a straggle Oh sides, it's actually sides is the ending with Fanta low sides are from ashwagandha. They all have the same core molecular architecture as our steroid hormones. And that's how they interact with the hormone receptors and they stimulate transcription of more hormone receptors, so you have more hormonal activity, so you need to clean the receptors. You with detox you need to multiply the receptors with the adaptogens and you need to keep the mitochondria in the cells that generate the hormones you need to keep the mitochondria high. So we see that the neuro, this neuro transmission and hormone side that neuro endocrine system depends on NRF two and amtk to keep the to keep everything clean, it depends on an ad and sirtuins to keep the mitochondria active. It depends on keeping senescent cells out so they don't downregulate, because that senescent pattern down regulates the production of the hormones. And of course, we don't want telomere attrition. So it's depending on all of those to keep a nice healthy system for it.

Awesome. Amazing. You mentioned one, one thing I saw that apart from like vitamin d3, in addition to these adaptogens was phosphatidylcholine. Yeah, do you find that like, do you find that something people generally need to supplement with?

Well, they should. There's some people that think that choline is bad, and it's creating certain stress. And it's choline is one of the most important things in the system, and the body turns it into phosphatidylcholine. But you can take phosphatidylcholine straight, so you don't have to do that. Now. phosphatidylcholine is an integral part of all of your cell membranes, and of the membranous organelles. Now, if you look at like electron micrographs, of mitochondria, or have the endoplasmic reticulum, see, you'll just see these folded up lines, it's just line line line line looks like an accordion folded up. And that's membrane all folded up membrane drives all biochemical power in the body by separating opposites. It's keeping the black and the white of the Yin Yang symbol, it's keeping that always spinning, and never coming together into grey, it's separating white and black in the body, like in the electron transport chain for making ATP, you're moving protons to one side of the inner membrane of the mitochondria where they build up, and then they rush back through the machine that is ATP synthase. And they generate ATP. So these membranes are driving this polarity and this coming back together polarity and coming back together, that's driving off the biochemical power in the system. And when the membranes get damaged, they can't do this anymore. And the outer membrane of the cell gets damaged, it can't bring in nutrients, and it can't get rid of toxins. So the whole cell gets disrupted. So in fact, you know, mitochondrial therapy in Germany 30 years ago was just phosphatidylcholine, injectable and oral, they would just do it all with PVC. And then the liver uses tonnes of Foston calling because it's dumping PC into the bioflow, all the time to fluidize, the bioflow and protect the bile tree from being dissolved by bio which is a detergent. And then in the brain. You're using phosphatidylcholine to generate acetylcholine all the time. And acetylcholine is your main focus neurotransmitter. And then the brain has tonnes of fat tonnes of membrane, and it needs lots of phospholipids for building it. So first thing choline is a beautiful supplement that is just like ambrosia for the body because it does so many different things.

It is amazing if I vary like my husband, and I have my husband or stills and then he's like kind of some of this brain fields.

That's exactly Oh my god. Especially if they've been mould exposed. And they're kind of like this. You give them PC. They're like, wow, the lights on. Yeah.

So awesome. Last piece here we've touched on all the way through is toxicity, right? Particularly like mercury interests me because like, for example, when I did a hair tissue mineral test, a few months back, I noticed that the only real toxin that was coming out on it was a bit of mercury and my selenium was low, which I think was being depleted by that mercury. I don't have any amalgams or anything like that that would cause that

from fish if it's Yeah, welcome form of Mercury does go through the hair, it comes only through urine and stool and sweat.

Interesting. Okay, so that would be from fish. It's probably because I like tuna. Yeah,

yeah. And then the ones higher in the food chain tuna, swordfish. They have all mercury in them. And so if you're gonna eat fish, you want to use smaller fish. If you're going to eat tuna you use like the chunk light or the skip Jack. You don't want the albacore the big tuna, they they can have quite a bit more hay on it. Sometimes you're talking about like a tenfold difference in the amount of mercury in these things. And when if you compare like a sardine or a Kipper, or an anchovy to tuna, you're talking 1000 fold difference in mercury levels. You can eat those as your soul protein force source three times a day and never become toxic. You know, you might build up PCBs are some fat soluble, but you're not going to build up mercury, mercury,

and what's the best way for us to eliminate mercury?

So the way you do Mercury detox and this is really, you know a model for how you do all detox. But say, you've got Mercury it's in a cell, and it's bound on to some protein in the cell. And it's blocking its function. Eventually, you'll recognise that you use glutathione. And an enzyme called glutathione, s transferase. And the transferase gets the glue the mercury to let go of the protein it's stuck to it will be stuck on what's called a sulfhydryl group to reduce sulphur group on there and be stuck on there. And it'll get the mercury to bind onto the sulfhydryl group on glutathione. That's why it's called glutathione. S transferase, transfers the toxin onto the sulphur compound, the sulphur end of the glutathione. So then you got a Mercury glutathione complex in the cell, how do you get it out of the body, you've got a transporter called the MRP, which pushes it out of the cell, and it uses ATP, which has cellular energy and magnesium. So we need glutathione, we need activity of these transferase enzymes, and we need magnesium and energy, we push it out of the cell into the blood. Now it's circulating through the blood, and you need the liver them to grab it, pull it into the liver, and then dump it out of the liver with the bile, then it goes down into the GI and then you want to poop it out. But the mercury can get reabsorbed. So you've we want to get glutathione levels in there, we can activate this phase two with any of those NRF, two up regulators that we need to couple that the bile flow to get into the GI. And then we need a binder in the GI to grab it so you don't reabsorb it, or it's going to go from the blood into the urine. If it's the amalgam form of mercury. If it's the fish form, it only goes through the bile and the stool. And so at a high level, if it's not a tonne of mercury, you just need to keep your glutathione levels up. And you'll keep moving it out. But you also get

FireFlow. Right? Yeah,

yeah, yeah. When you're really trying to get a Mercury detox going, then you need the glutathione. You need the face to activation, you need the bioflow. And you need the binder. And you know, we put all those packages together. I mean, even if you just did the push catch liver detox and some glutathione, you would do a good job on getting rid of your mercury.

Oh, super interesting. I think you've shared so much. Thank you.

Yeah. Once you get into it, and you see how much everything is interlinked. First, it seems even more complex is it's like you just want to think one thing at a time. But eventually, you come to see the whole thing happening. And you're just supporting a clean system with all the resources for all the interlocking pieces to go and like I said, you either get on this side of it, the good side, the co2 inside, or you get on the shit inflammatory processes side, and you're gonna die early. Right

and feel like shit you're doing that's the thing. How long do you reckon because I was reading I think was on PubMed I was reading, I think it's actually an interview with you about like, we don't we haven't proven yet right, that we can get past 120 necessarily, what would you say? Like for people looking at this? Do you think we can get to a point where we this is my dream? Why is you feel so good for your life? So you have amazing healthspan it's less for me about how long can I live, but you feel amazing to the end, right? And then hopefully you just go to sleep.

Yeah, that's it, you know, you want to run into the end of there's a American movie called The Blues Brothers. And these guys drive this old cop care car around, and they're, there's huge car chases that are all over the place. And then they get to their final destination they get out of the car, they close the door, and the whole thing falls just into pieces, like and that's how you should just slamming into the end and you just die like that. And, and that doesn't, you know, we don't need to get past 120 I mean, I get really tired of this world. You know, it's people aren't really all kinds of stress all the time. And it's just like, What the hell with this, let's leave and do something else. But I think we should routinely, like we should live really strongly past or 80s We should pretty easily get up to around 100 And, you know, some people will make it longer someone and then we check out. But you know, it's like, now our 60s should be really solid, you know, we should be really still cruising. You know, I'm 54 now and you know, I still hit the world pretty hard. And I intend to do that, you know, maybe slow down in my 70s a little bit. And you know, and just each decade just be a little a little less aggressive, but we should be able to live really full lives. into our 80s Do

you think we can look good doing it? Do you think we can avoid the wrinkles? everyone's obsessed with just putting things into your face to avoid it? Do you think we can naturally avoid these wrinkles? Yeah,

yeah, the more we learn to take out the senescence cells and keep the telomeres up, and you know, the use, you know, the, the longevity wheel itself is going to keep a lot of that at bay. And then we're going to use peptides and stem cells to really supercharge the longevity, and I think we'll be able to do that. And, you know, and then there'll be like, you know, not necessarily fillers, but there'll be topicals that supports in essence topicals that support, you know, that are, you know, growth stimulators, you know, like exosomes going topical, peptides going, topical, and we'll be able to look good. I mean, there's only so much you can do, you're not gonna look like you, when you're 70.

They're gonna lose. Yeah. And what,

you know, I was, with one of my favourite corpsman doctors, Lauren Brandley, we did a, we did an interview together. And you guys are in good shape, because you're starting early, you know, we didn't really come to this stuff until it was like too late, you know, like, a shit. You know, I've been running this company, so long have totally grey, oh, wait, there's all these longevity, things that start taking those, they really just came on the scene. And so if you start doing this, you know, certainly in your 40s. And what she was saying is the 40 to 50 decade is the most significant ageing that we will see that the flip between those two is kind of jarring. And you're like, Whoa, that was a big jump. Now, I feel better.

It's as true for men as it is for women. Yeah. Oh, yeah. Okay, interesting.

Absolutely. You know, that's when, you know, if you're gonna lose it, you lose your hair, and, you know, it goes grey. And until you jump on these things, and bring them back, you know, you know, it's a pretty significant decade. So if we start these things in our late 30s 40s, and we're doing that maintenance to keep all the, you know, the dead cells out and stuff, get rid of the senescence stuff, stimulate telomeres, and all these things, we will look better in, you know, in in our late age. You know, for me, it's like, you just got to stop the ageing.

Because I was gonna say, Hang on a minute, forever. If anyone that can't see you, you have amazing skin. You have great skin. So this is this is not true. Yeah, I think you're being a little harsh that people generally

like, you know, your skin is pretty good. That's, you know, at some taken phosphatidylcholine all the time, you know,

that's good for the team, you think? Yeah. Oh, yeah, it's

a really good one. I

ran out getting some more of that. This has been so much fun. Thank you so much. I feel like I could go on and on. But I want to be respectful of your time. So thank you so much. Where can people find you? Where can they buy in the UK? How do we get hold of Quiksilver? We can buy it right? There's different companies that do it as well.

What is it skinny raw,

i and i get it as well from Amrita nutrition, Rita. And

I think it's skinny raw, you can find it on our website, there's a list of international distributors. And those two companies are the ones there's also one called the HUD group, which is an online they have some of our stuff, it's a direct to consumer, it was just released. And we just opened up that site in the UK, so you can find them on there too.

I will list those because I'm Rita is practitioner now. And I want to do direct to consumer. So thank you. Well let those

direct to consumer and I think skinny rod does it too. And

then if you're in the US or Canada, straight to Quicksilver, or straight

to Quicksilver and we have a we do have a store on Amazon as well.

Awesome. We will link to that. Where can people find you if they want to connect with you?

Yeah, so Dr. Christopher shade on Instagram, Quicksilver Scientific, on Instagram, there's Facebook, Quicksilver Scientific, as well. And of course, if you just get on to our website, and sign up for our newsletters, you'll get a lot of the activities, you know, things that we're doing, you'll be kept up to date on that. Your practitioner go onto our website and get a practitioner account, even if you're getting from a distributor for you're in another country, because that's where all of the education resources are there behind the login there for the practice. There's a lot of resources on our website, but if you have a practitioner account, there's vastly more available to

amazing I've made a note of that myself. Thank you. Thank you so much for coming on the show.

If you're a practitioner and you want to learn more about how to do all of this. Not only are there 30 webinars that have done in the practitioner resources but there's a learning management system called Quicksilver Scientific Institute. And if you go in there, it's free to use. There's a detox module that takes you through metal testing, metal detox, general detox, gets all of this. It gets you wrapped around all of this. And we have a hormone module coming that teaches you how to use our hormone line as well. Awesome.

I'm gonna dive in there. Thank you, and I'm sure many listeners will too. Thank you so much. I hope today's episode inspired you on your journey to vibrant health and high performance make sure you check out the show notes for a summary of all the important links to everything we talked about. And if you enjoyed this episode, hit the Follow button and share it with a friend on social media. We'll leave a review over on Apple podcasts. Remember achieving high performance health is about getting 1% better each day. So think about one thing you learned from today's episode and start implementing it today. share with me what you've learned on social media over Angela s Foster. I love hearing from you and connecting with you have a beautiful day and always remember you are worthy of your dreams.