thank you so much, James, for your kind introduction. And thanks to the foresight team for inviting me. And thanks to all of you who are attending at what I would consider past my bedtime for some of you. So stay with me, I hope I'll keep you awake, with my take on molecular machinery, because I have a sort of fascination as all of us with the molecular machinery of life. And My take is that instead of building molecular machinery from scratch, which of course has made incredible advances in recent years and decades, I would rather hijack the evolved over billions of years molecular machinery of life and endow it with new functional properties put on new ignition elements, control elements, which is to be able to turn on and off and shape its its performance. And we have done this mostly with light, I should say that we are also interested in using magnetic fields, for instance, to do this in ultrasound, but this is not the topic of today's lecture of this talk, rather. And please interrupt me at any point to sort of Formula a bit off track. What I want to tell you about today is the use of synthetic photoswitches and their merger with some of the best studies and best understood molecular machines in sales in order to in order to control cell functions. But of course, we're also interested in the individual molecules themselves. What I like about this approach is that it's relatively easy to address these machines, right, because they're kind of wired up for expression in the male brain. And then you can interrogate them for instance, with electrophysiology and other methods. Let me see what I can advance my slides here. Yes. So here is a sample of the machinery we have been working on. We started our work some 1518 years ago, and I actually with voltage gated ion channels, which of course make these wonderful movements across the membrane in response to changes in voltage opening a gate letting ions flow. And then we have progressed from voltage gated ion channels. Over the years to ligand gated ion channels such as ionotropic glutamate receptors such as pentameric ligand gated ion channels, for instance, GABA a receptors nicotinic acetylcholine receptors. Today, I will tell you quite a bit about G protein coupled receptors, because they have been a wonderful platform for photo pharmacology where we put synthetic photos which is on I won't tell you much about arguably the best studied, most famous, at least, molecular machine at present phase some years ago, we published a small molecule photoswitchable molecule that functions like a photoswitchable range, and was able to control the f1 fO atpase with light in that way. But we've only done biochemical studies and the sort of mitochondrial targeting versions is still not ready for publication. So I want to wait a little bit before I can say show you some Sarah work. But we have also worked on, for instance, on exciter amino acid transporters. And we have actually very nice paper in development with Paul Neeson on zerker on the sarco, endoplasmic reticulum, calcium atpase, which we can also switch with a photoswitchable version of topical toxic algal control. And then we move over the years a little bit more into Sailele I have really fallen in love with the cytoskeleton with its highly dynamic nature and its fascinating movements, it allows and enables. And this dynamic instability, dynamic of the of acting and tooling for instance, we could control with photos which will molecules and we'll throw a little bit into there about an attempt to control a Kenny's in spindle Kaneez in called egg five with the photo switchover inhibitor, which is not published yet but which we are soon going to publish that allows us to control mitosis with light. And then it is a work on transcription factors, nuclear hormone receptors, a lot of work recently has been done on photoswitchable lipids because these so benzene photos, which is you guessed it, which I'm going to focus on today, they are absolutely a match in heaven with with fatty acids. There are lipophilic molecules that can have cysts, double bonds, if you treat them with light, that's what you'll find in lipids, for reasons and since I can impart this with light, we can do some pretty cool lipid physiology, but also some very nice membrane biophysics with photoswitchable lipids and there's a whole series of papers in there, already published, I can tell you that we have been able now to feed photoswitchable fatty acids to certain cells. And we find that up to 40% of the endoplasmic reticulum of the phosphatidyl