Peptides, BioRegulators and Reversing Biological Age with Nathalie Niddam

12:15PM Sep 11, 2023

Speakers:

Angela Foster

Nathalie Niddam

Keywords:

people

regulator

peptides

bio

body

ageing

work

health

longevity

pineal gland

supplements

stress

sleep

essential amino acids

started

podcast

years

talk

women

nad

bio regulated peptides are naturally occurring in our bodies, we make them, right. It's just that, like so many other things, we make less of them as we age. And we probably like make less of them when we're under stress when we're exposed to certain target like all of those things that can dampen the system.

You're listening to the high performance health podcast helping you optimise your health performance and longevity. My name is Angela Foster, and I'm a former corporate lawyer and high performance health coach. Each week, I bring you cutting edge bio hacks, inspiring insights and high performance habits to unlock optimal health performance and longevity. So excited that you've chosen to join me today. Now let's dive in.

Hi, friends, I thought I'd give you a bit of an update on what I've been up to recently. So I've recently been tracking both my nervous system and my blood glucose quite closely to really get a handle on how what I'm eating and my daily stress levels are affecting my blood glucose. And it's a topic we're actually diving deep into with my members of the female bio hacker collective. And I've had some really interesting observations, there are some very cool ways of measuring this and looking at how the fitness and nutrition and stress also play a part. And I really like the way the very app interacts now with your ring, so you can actually see the effects of blood glucose on sleep. And also through its integration with Apple Health. It allows me to see the effects of my workouts that I currently track or my whoop strap. So I like all these kind of API integrations, they work super well. And I think CGM is are one of the best ways to create behaviour change, as you can see the results of what you're doing so immediately, but many people actually need some help understanding and moderating the effects of stress and fitness and nutrition in a positive way. And so that's what we're diving deep into with my members this month in the female bio hacker collective. And something else that I've also been really impressed with is a new supplement by biostat labs called GD eight, which I take before a carb heavy meal, sometimes, right you just want to indulge a little bit and I find this to be really powerful and stabilising blood glucose which is important obviously, for overall longevity. But also if you're someone who's looking to burn more fat, and when our blood sugar is high, we released the hormone insulin and insulin actually blocks fatty acid oxidation. So if you want to burn more fat, you need to take control of your blood glucose. And the gda is a really powerful strap stack with extracts of bitter melon and dihydrate Berberine dihydrate. Berberine is like nature's Metformin, and it also has chromium which helps stave off food cravings and enhances blood glucose control. And biostat labs are very kindly giving listeners of this podcast a free bottle of GED aid with their powerful NAD enhancing supplement NAD region. It's actually the only company I know of outside Tony Robbins company, lifeforce that have NAD three in it, but it's also stacked alongside niacin, amide, resveratrol, and spermidine. And I think honestly, I can actually credit my recent hair growth to the spermidine. Anyways, if you'd like a free bottle of gda with your purchase of NAD region, go to biostat labs.com forward slash Angela. And you'll get an awesome stack for enhancing your longevity and taking control of your blood glucose. That's at biostat labs.com forward slash Angela. But if you're like me and listen to podcasts while you're working out or walking the dogs, you probably never remember the link. So I'll also put a link in the top note in the show notes. Now in this week's episode, you're going to be hearing all about peptides and bio regulators, which are these incredible compounds that can trigger the body's healing mechanisms and even help to reverse biological age. My guest is Natalie Needham. She's a certified holistic health coach and self proclaimed science geek with a passion for human health. And she's also a total expert in the world of peptides and bio regulators. So if you don't know much about these, you're about to learn a whole lot more.

So Natalie, I am so excited to have you here today. We just been chatting offline all about longevity and anti ageing my few of my favourite topics. Firstly, a very warm welcome to the show.

Thank you so much, Angela. It is such an honour to be here. You don't know this. And I didn't tell you this beforehand. But I actually years back was trying to build a website for a business and I came across yours. And I went to my designer and I said, I want a website like her website. So seriously, you know, oh, thank you. I

had absolutely no idea. I can't actually remember exactly how we connected in the end. But I love your Instagram and I love your work. And so I'm just really happy to have you here. We saw each other fleetingly their health optimizations I mean, 60 seconds, but it would have been great to catch up maybe another time in person,

for sure. No, it was. It was a busy it was a great event. And it would definitely had us running the whole time.

Yes, it did. It was brilliant. There's so many people. And your talk was amazing. So let's start. Why don't you introduce how have you got into the whole realm of anti ageing, peptides, longevity, everything that you do, which is just right at the forefront of biohacking this?

Well, I think ageing is a good reason to get into

or not ageing.

But you know, it's funny, I think I mean, I've always been interested in health. And even before I got into this profession, if you will, I've always believed that the human body has the capacity to repair itself. And it shows us this day in day out, right when maybe a bit better when we're younger than when we get older. But if we think about really what's happening in the body, on an every minute of every hour of every day, it's a flipping miracle. Even sick people can draw breath, there's all these chemical reactions going on. There's, there's all these different processes happening. And so I've always held this fascination with health. I started off in university studying physiology, I kind of strayed a little bit through my life as I ended up in the corporate world for many, many, many years. Until one morning, I woke up and I'm like, Okay, I'm done with that. And I went back to school, I became a nutritionist the whole nine yards. And as you know, once we we go back to school and get a certification like that. It's it's not the it's not your actual career, it just opens the fan of what's possible in terms of where you're going to direct yourself. And this whole idea of, of health and slowing down, the ageing process really started to take hold a few years in. And then I got exposed to peptides at a conference. And it was one of those moments that really defined what was what unfolded for me since then. Right that like, that's when I started my Facebook group. A year after that I started the podcast. And really a lot of that was about how do I get people who know more about this stuff than me to talk to me?

That is the amazing thing about our podcast, right? I get to, that's what I love about my podcast is the people that I meet. It's just incredible.

Yeah, and getting to pick people's brains like it's just yeah, and then offer that up to your audience as look what I found and and look at what's out there. And it doesn't mean that every single person we interview is the be all end all. But they're all pieces of the puzzle. You know, like I interviewed Dr. Bredesen last week I'm sure you've spoken to him and if not, I'm happy to introduce

you haven't yet but I would Yeah, love and oh my god, the

nicest guy but but here's what's interesting is even he will say as much as he's made such massive inroads into helping people to slow down, stop and even reverse Alzheimer's, write a condition the doctors will tell you over and over again. No, not can't be done. You're done. Say goodbye to your family and write a book. He even said to me, he said, you know, with all the work that I've done with that big body of work and all the success we've had, it's still just a piece of the puzzle. There's still other pieces of the puzzle that we continually are fitting in. So you get a you get a researcher like like blanking on his name, Dan good. Now, Dr. Day and good now who study discovered plasma halogens, and found that they can actually help to rebuild white matter in the brain. And so you've got that body of work that's going to feed into all the other pieces. So I think on the on the healthy ageing front and how I got into it is just after talking to people like talking about peptides, peptides and starting to realise, wow, there's peptides that can slow ageing, there's peptides that can maybe reverse ageing. But then realising peptides are amazing. And there's so many other things that have to come into play. Right? You can, the body has this incredible ability. But in modern life, we are being exposed to toxins and toxic elements on a constant daily basis, we have to be able to help our bodies to remove and to deal with that stuff, so that it doesn't get in the way. And then beyond that, we also need to be able to provide our bodies with the building blocks that it needs to do the work to respond to the signals, if you will, that we're initiating through these peptides. So I always use my burning house analogy. And you know, you can't send the best Contractor sent into a house the house of a hoarder that is filled with junk. If you don't allow him to clear out the junk, he's not going to be able to do a good job for you or do any job and then taking that step further. If he doesn't have any materials. He's not gonna be able to do the work. So the body is no different. We have to end and you know We keep thinking about what supplements can I take? What can I do? What can I add? What am I bringing in? And very often I find we all fall prey to this forgetting about what do I need to eliminate what needs to be removed? Before I bring in these things so that there's time and space for the body to do its thing? I don't know if I think I kind of went off on a tangent. But that's more or less how I got to where I am.

Awesome. Well, thank you for that, with when we're looking then at kind of what we might want to eliminate let's start there before we bring things in, or even, maybe a better way to approach it would be to think, what's the baseline that we need to establish everyone? I think the thing with with supplements is, it's really not that much different than going and getting a prescription right at the end of the day, you're taking something that you hope will be a magic pill or a magic solution. So what is the foundation that you believe that we all need to start with? Is there a particular style of nutrition that you advocate, for example? Or is it about kind of embracing diversity? Obviously, sleep, we need to nail exercise all of these things? I kind of use a shift protocol for this. But I'm curious as to what yeah, what kind of foundation you'd like clients to lay in place, first of all,

yeah, and I mean, you know, it's, it's, I mean, to those of us in the business, it may it's, it seems pretty basic, right? And like you said, optimising sleep. If we're not optimising sleep, nothing's gonna go well, you're not gonna be able to manage your diet properly, your body's not gonna be able to recover your brains not gonna be able to clear out the toxins from the day before. Like all the things so optimising sleep managing stress, we live in a stressful world, every generation before us has lived in a stressful world, I would argue that our stresses are starting to like overflow these days. So learning to manage that stress learning to build resilience in your system, so that the stress will be there. But it doesn't affect you directly, as as it could, right. I mean, it's very easy right now to walk around worrying about any one of 27 things at any given minute. And so how do you find that inner balance that allows you to not feel like you're being chased by a lion every minute of every hour of every day? And that can be as simple as breath work? It could be as adequate go as high level as technology, right? So whether it's a device like a sensate or a neuro visor, or whatever the case may be, or is it learning to meditate, if that's if that's available to you, at the end of the day, that's probably the best, most efficient way to do it. But then we've got escape routes, we've got things like exercise and movement, and which can also help to mitigate the effects of stress. Plus, it keeps our body healthy. So we've got Exercise and Movement, we've got managing stress, we've got sleep, you asked about diet, I'm not I'm a diet, I'm diet agnostic. My feeling is that there's going to be an optimal diet for different people at different times of their life, what serving you today may not serve you tomorrow. And as women especially, we know that right when we're in our childbearing years, when we become Peri menopausal, things start to shift, postmenopausal things start to shift again. So how you we, and we see this every day, we see when we hear from women in our business, we hear from a woman who's like, Dude, I didn't change anything. I woke up one morning, I looked down and I don't know who the hell swapped out my body. But this is not the body I've been living with my whole life. And so things signals change, the body changes, we have to, we have to evolve and move with it. And I think men also like as their lives change, they have to change their nutrition. So I'm not a huge fan of the extremes. I'm not a massive fan of vegan diets or frankly, carnivore diets for the long term. I think they can be really great interventions. I think that my personal opinion is that for most people, focusing on nutrient density, and focusing on optimising your digestion and and being as unemotional about your food as possible, trying to allow your needs physiologically to drive your your dietary choices versus emotions is would be ideal. If we can get there

if we can get there. And yeah, food is so emotional for so many people, this is the best becomes

such a trigger, right? I mean, I think like, you know, in some camps, you will almost feel like there's a war on animal protein right now. And I don't think that's going to serve us in the long run. I think paying attention to where our proteins coming from paying attention to proper farming techniques and the whole nine yards. I'm all in but I think that this This, you know, this this thing that's happening where it's becoming a political issue is not a good thing? I really don't think so. So anyway, so and there's you there

on protein actually, can we pause there on protein for a moment, because you put out some interesting content in relation to that the other day saying a lot of people reach to get more protein because they believe that's what they should happen, particularly women, obviously, as they go through perimenopause. But actually, what you need is not so much protein, it's amino acids, which is what protein is broken down into. And I think I think you shared that you will drink an amino acid drink maybe a few times a day. I'd love to just yeah, just interrupt you briefly there to talk about that.

Well, so I mean, so that they that discussions really is around essential amino acids, right. So those amino acids that are the building blocks of protein that our body used to repair and build. And so it's really hard through diet to get in enough protein, not to mention the fact that many, many people, most people's digestion is not optimal, we're not breaking things down properly. And if we don't break them down, we can't absorb them. And if we can absorb them, we can assimilate them. So the essential amino acids really is a bit of a gift to the body. And it says here, you don't have to work for this, I'm just going to hand you this kit that you can use for whatever we need right now. So whether it's recovering from a workout, or repairing from an injury, or, you know, I also find that essential amino acids, there, they they run the gamut, right from the elite athlete who might be pounding like five or six servings a day to meet the needs of their body to rebuild to an elderly frail person who doesn't have enough of an appetite whose digestion kind of sucks, but who desperately needs those essential amino acids to repair and to keep themselves going. So there's, you know, even recovery from from surgery or from injuries, like there's literally nothing that those essential amino acids don't apply to. And it also, it doesn't replace protein that we eat, particularly but as a supplement. It does provide your body with those building blocks in a way that's really easy and bioavailable.

And your body intelligently knows what to do with them. Have you found any that taste half decent and aren't packed with sweeteners because this is the perennial challenge. And some of them if you get sort of the plain ones, they actually just they kind of release nausea, they're just they are hideous, they almost smell like vomit.

And even some of the flavoured ones are you kind of like there's no better way to record drink? No. So I have to say that so there is there's an even within a certain brand. There'll be certain flavours where they were able to mask the the nastiness better than others. I would say that my default though is I take the pills. Yeah, they're kind of chalky, though, right? So so there's a company that coats them. Ah, they have a coated or uncoated version and I will say the chalky ones they uncoated are they at least 30% of the time we'll get stuck in your throat no matter what you do read letter size. Oh, yeah, no, they're big and they're sticky. I actually think you're almost better off throwing those in a smoothie if you have a Vitamix and blending them in because they won't actually taste that bad if it's a good if it's a good shake. But I like the I use the coded pills. I use the ones from Buddy the the perfect aminos because they have they have a giant bottle that lives on my counter. And you know, my son and my husband are instructed to take what they want when they want

and what dose Are you taking when you're when you're sort of supplementing with them?

So I'm trying I mean right now I'm I'm actually moving into a new protocol and I'm going to be using 10 which is a double dose before my workouts and then 10 before bed and

to kind of what sort of stop that catabolic effect are you doing that fasted your workout or

printing? Yeah, no my workouts I don't like eating before my workout and there's the the best way in my world to sabotage a workout is to have something to eat before.

Same Hey, I'm totally the same. I've tried it and I just Yeah, I can't

do it. I mean, my husband needs before during and after a workout. I'm like, I have no idea how you do it like the body's physiology demands that your blood flow moves away from your your digestive organs and towards the arms and legs. So it is a mystery to me. Unless it's something like essential amino acids like I think an eh during, during or before workout, obviously is going to have some benefit because it's it's it, it just gets picked up by the body and there's no work involved. There's no digestion.

So super well. And what about you talk about amino acids? Are you also? Do you? Are you a fan of taking collagen?

Yeah, I mean, I get collagen in all kinds of places like I, you know, I drink a mushroom coffee right now that has collagen in it, or I've got my collagen drinks on the side or, you know, there's the, there is another, I mean, I don't want to be dropping brands all over the place here. I've got I've got a few definitely, I am a fan of collagen, for sure. But I also eat me and I also drink bone broth. And I do think that too much collagen without the other side, you end up what does it mean finding that you end up a little depleted in so you know, it's this brings us back to that discussion around as much as we can to, to have a very diet so that you're bringing in all those elements and you don't you know, it's like, like the vegan diet, which can be really great for people at certain points in time to do a vegan diet properly and not end up deficient in a bunch of stuff. It's a tonne of work.

It's a bit like trying to do the keto diet properly and not put yourself at risk.

Exactly. It's hard. All of these extremes are a lot of work to do properly. And you have to be willing to do the labs, do the blood work work with a practitioner? See, are there any deficiencies or even Are you building up certain things that you don't want too much up, for example. So that you can kind of course correct as you go.

It's very true. So we have stress obviously dialled in, and I love the way you've pointed out their breath work meditation, like relaxing, calming practices, as opposed to what's common on social media, which is I feel really stressed or and I want to reverse and like my, my ageing protocols. So let's just pile in more stress, right? We've hit workouts and ice baths. And

now my sleep.

Exactly, let's not, let's not just sit in quiet contemplation. So anyway, that was very good, stressed sleep nutrition exercise. I feel like I'm now getting outside in nature. grounding. I feel like now we can jump into the fun part that you specialise in. Yeah. So for someone like myself, and probably many of the listeners, who is looking to slow down the ageing process, what are your goatees? Where should we start?

So my my, the thing I've been talking about the most over the last couple years have been this whole kind of subset of peptides called Bio regulator peptides. And the bio regulator peptides are really interesting in that these are in their, in their initial form, the form that was originally discovered and studied by Professor Kevin Johnson in Russia, is they are essentially very refined extracts of tissues, glands and organs from animals. Bio regulated peptides are naturally occurring in our bodies, we make them, right. It's just that, like so many other things, we make less of them as we age. And we probably like make less of them when we're under stress when we're exposed to certain times, like all of those things that can dampen the system. And I don't know that they've all been elucidated. But ultimately, as we get older, we know we don't repair quite as well. Now, cabinet, Professor Davinson will say that in every organism, and this goes from plants, to animals to humans, there's a 30 to 40% Biological Reserve. And he speaks to this as in, you know, most people can easily lift to 80. But not a lot of people will make it to 120, which is kind of like the accepted natural health span of humans. Right? We you know, in the 19th century or the 20th century, we kind of got rid of most infectious diseases for the most part until a couple of years ago, but we're not going to talk about that. Think people, right, yeah. And so now we get to worry about, okay, how long am I going to live? And how well am I going to live in the into those years? And that's the real crux of it, right? Because for the longest time, it was longevity, longevity, lifespan, lifespan, lifespan, and then all of a sudden, somebody woke up and said, Well, wait, hold on a second. We could stay alive a really long time today with today's technology, and we're seeing it. But now, we're gonna up the ante again, we're gonna say no, not only do I want to live a long time, but I want to be I want to have my head together. I want to be independent. I want to be able to move and hike and enjoy my life. So now we're moving into the space of healthspan. And in order to have healthspan we have to have a mechanism by which we're restoring function we're in to our tissues, glands and organs as they just naturally were out just before we talked about toxins and infections and all that stuff, which actually that is one other thing I would add to that previous conversation we just had is addressing any underlying chronic infections and toxins like things like heavy metals, or EBV, or all of these kind of, you know, tick borne diseases, mould, all of these kind of under the, under the line, things that are kind of chipping away at your immune system and ultimately, compromising your body's ability to function at its best. So that's as much as I'm going to say that. So getting back to the slowing down and reversing biological age, you know, we have natural methods to a point that are available to us things like fasting if we do fasting properly, and we do it often enough, long enough so that we actually do stimulate a toffee G, which most people don't. I think that fasting and caloric restriction has been shown in studies to be an effective way of slowing down the ageing process. When it's not over when you don't overdo it when your body's ready for it, the whole nine yards. The bio the bio regulator peptides are essentially epigenetic switches that slip on genes that signal the tissue gland or Oregon to produce proteins that help to restore form and function to that tissue Glendon Oregon. So for example, if we look at, you know, one of the the one bio regulator that probably most people, if they've heard of by regulators at all have heard of, would be EPA Talon, or a petal on or endo Luton or epithelium. And so the one of the nightmares at the bio regulator world is that each bio regulator has on average, at least three names.

Right? Okay. Which just makes it super confusing,

super confusing. And they're not always descriptive of what well, they're most often not descriptive, but in any event, so a petal on or any of those other names is the Pineal Gland bio regulator. And the reason why it is a fame, if you will, is because we know that the pineal gland really regulates so much related to ageing in the human body. It is a master endocrine regulator. So from a downstream effect, it helps to, to to rebalance hormones. Now, it doesn't mean that if you take this bio regulator, your hormones are magically going to balance overnight, but it is going to contribute, right? It is the pineal gland is central to melatonin production. Well, a piddle on in studies was shown to normalise melatonin production in elderly adults. And as a downstream effect, it optimise their sleep, it helped with bone density, it helped them with their immune system. It was it was supportive of a whole bunch of foundational aspects of health. And in the studies that Kevin son did on elderly adults, he was able to show that just the pineal gland on its own used for two years, reduce their all cause mortality versus a control group that didn't get a pedal on. And instead what vitamins.

And how easy a petal on is when you say it's a bio regulator. It's approved for human consumption. So we can we go in as as

a nutritional supplement? Yes. Yeah, so the nutritional supplement. So it's basically these are capsules. And these are these are classified as nutritional supplements, where we start to get into the grey zone is when we get into the synthetic bio regulator, like a piddle on so one of the things about the names is epic. Dalaman is the actual extract from the tissue gland or from the front of the pineal gland that has been prepared for intramuscular injection. That is, that compound is almost exclusively available in Russia. There, nobody's exporting it out of Russia, so it's really hard to get outside of Russia. We then have the capsules and gluten, which are also an extract from the pineal gland, but they've been encapsulated and they are for oral use. So now you're gonna say to me, Okay, now here's the thing, a bio regulator peptide, is a peptide peptide as a protein, does it not get digested in the gut? Which would be a really fair question. So the way that Kevin explains it in his literature is that these these sequences of amino acids are essentially because they're native to the body. They're almost the recognised by the body as a compound that can be used, and so they have transporters in the gut, that will transport them in through the gut lining into the bloodstream and there they will make their way and find their way to where they need to go.

If you listen to this podcast, you're probably like me, a busy mom, entrepreneur, biohacker or other high performer and that requires a huge amount of energy and resilience to deal with life's challenges on a daily basis. There are two key supplements that I love that helped me to do this. The first is biostat labs NAD region, which supports NAD in the body, and ad is known as the molecule of youth and is critical for energy. Taking NAD region helps me maintain high energy every day, so I can achieve more in my business and also show up better for my family, all while protecting my longevity and avoiding burnout. The second is GED aid biostat labs unique blood sugar formulation. Managing your blood sugar is also essential for high energy, cognition and longevity. GED aid combines dihydrate Berberine often coordinators Metformin, with the very best ingredients for all around metabolic health, this product is like having your cake and eating it. I take NAD region in the morning, and gda just before my most carb heavy meal of the day to blunt the glucose spike, and now on to help you to support your energy metabolism and longevity. So you can truly show up as your best self. So I've organised a unique offer for you my listeners that's not available anywhere else. When you purchase two bottles of NAD region biostat labs will send you a free bottle of Gd aid, simply go to biostat labs.com. Forward slash Angela to get your free bottle. That's biostat labs.com forward slash Angela to get your exclusive offer. I'm inviting you to join our newly opened high performance health Facebook group where we're all about unlocking our utmost potential. If you are a fellow biohacker, a coach or a woman with an entrepreneurial spirit looking for peak performance, and our community of ambitious women is just for you. But it's not just about connecting with like minded women. It's about empowering each other. We have weekly live training Q and A's and a bunch of other exclusive content that I don't get the chance to share anywhere else you buy or hacks I'm exploring, plus extra nuggets of wisdom from my podcast guests, and so much more. It's free to join, simply click the top link in the show notes or go to Angela foster.me, forward slash h P h. That's Angela foster.me. Forward slash HP H or click the top link in the show notes. And once inside, send me a message so we can connect personally, I can't wait to see you. How easy. Where can you Where can people get ahold of these.

So there's so at this very instant, there's a bit of a problem with availability, I'm not gonna there's been some issues with you know, there's some politics involved all kinds of stuff, but there's actually a company in the UK. And you may already know of them. It's the website, it's profound dash health.com. And they market all of the cabins and pet bio regulators. And what they've done is they've created a new brand called nature's marvels, which repackages the scary White Russian box with the Russian writing on it to a very pretty coloured box that gets rid of the whole name problem, because it just says pineal bio regulator, blood vessel, regulator, heart by regulator, they don't bother with all the crazy names. And it's got a pretty picture of a field and a sunrise. It's all very, very friendly. And so those are

very friendly. Sunrise.

Well, you can imagine the guy at customs, in the current climate, receiving a big box of these boxes with a lot of Russian writing, he can't read on it. Going, yeah, no, that's not gonna work.

What the hell is that it's not coming in. Sorry.

I don't know what to do this is but we're not letting it in. So the other thing is that there are now a Kevin sin has also been developing successfully sublingual sprays that deliver the synthetic version of the bio, that bio regulator. So what that means is in epithelium or endo Lewton. It's actually a complex of peptides, right? It's not just going to be one thing. But what they've done is they've isolated in many cases, one or two of those amino acid sequences in that bio regulator that really hit the mark. And so EPA Talon is the name of the synthetic bio regulator that is a four amino acid peptide, I'm pretty sure it's four. I don't think it's three. I think it's four, four amino acids. And so it's just the money shot. So with the synthetic, it can either be introduced into the body as a sub q injection, and that's where we start to get into that really dodgy grey zone? Because where do you get it? It's usually a research lab, it's technically a research chemical not approved for human use. So you're starting to, I mean, I can see your, your legal brain starting to smoke there.

As well, I'm just as you're saying it, I'm just aware of how many people will go on to, you know, a website and then just start injecting and it's injecting in the same place over and over and it sort of concerns me as well. Because

it should yeah, no, I mean, there's anyway that's that's all you know, we could do a whole other point similar. But, but the the synthetic bio regulators now are also coming out as sublingual sprays and sublingual drops, because the thing is, they're so tiny, but they actually can be absorbed through the the oral mucosa in right into the bloodstream. Yeah, which is kind

of which is a good place. That's very cool. I mean, I was actually going to ask you that, on your thoughts when you're talking about the pineal gland, and like absorption through the mouth and things, how worried you are around things like fluoride and their pineal gland, for example.

Yeah, I mean, I think Florida is a massive issue, right? That whole, that whole, that whole column in the of the periodic table is a massive issue. And so as we said earlier, we want to avoid, we want to try to avoid the things that are negative. So reduce your exposure to fluoride for the love of God, there's so many good alternatives on to the toothpaste front right now. And then if it's, you know, in my world, fluoride is added to the water for some reason somebody at City Hall believes it's really important for us to be drinking fluoride, go figure. So I use a reverse osmosis system in my house and then I read mineralized, my water like all the things, I remove fluoride, so I do everything I can to reduce my exposure to fluoride, and then I will use whether it's no gluten or a piddle on on a regular basis to kind of give that signal to my pineal gland. And normally, I didn't you know, I didn't finish on that one. It normalises it resets circadian rhythm. It normalises melatonin production, it activates telomerase to help to restore and maintain the length of telomeres. Which, you know, it's not a straight line between long telomeres and healthspan and lifespan. But you sure don't want super short telomeres?

No. And is it? I mean, are there any downsides to taking it?

Not that I've seen any evidence of okay, so Professor Kevin gets asked that question a lot. And he will say that in you know, he's been researching these knees for 40 years. So this is nothing new. It's not, you know, the information hasn't necessarily percolated out to the West for 40 years. But it started out as military research, which is usually a pretty good indication that it's important stuff. And he's, I'm and I, in my, you know, in my community of now, over 18,000 people that's been around for four years, the only time I see someone having a negative response is if they are extremely immune sensitive, let's say like they have a very overactive immune system, or they've got some kind of serious autoimmune issue going on. And they are going at it too hard too fast. Generally speaking, if we in those people, it's a good idea, frankly, they have to do everything, everything else, right. Even if there's starting a new supplement, it needs to be taken out a quarter of the dose, maybe even less before they they can build up to a level that they can tolerate. So for the most part, I'm there's I haven't seen read or experienced any negatives. So one other distinction that's probably good for people to know is between the synthetic bio regulator and the the biologic, the extract, if you will, like that nutritional supplement, the way that what we've seen, and I know the way that in Russia, the way they apply these is the synthetic is what they will use for people who are more sensitive and have more health issues. And it will generally take action faster, but the effects may not last quite as long. Whereas the oral bio regulator, which don't forget, it's an extract, so it's going to contain cofactors. around that, that peptide, if you will, it might take a little bit longer to take effect, but it seems that the effects once they're achieved, will last a bit longer. And could it be that some of these cofactors are helping other things to happen with that tissue? Right? I mean, it's they're really a little bit like desiccated organs. I think it's just a more refined form.

And what would people see when you say it takes a little bit longer for the effects, what length of time and what could people expect? To experience?

Yeah, it's a good question. And it's a really hard question to answer because it depends on the person and where they're at. So I'll say that, you know, for example, I've seen women who, like younger women who are still in the reproductive years, who, for whatever reason, stopped having a cycle. I've seen them get their cycle back by applying both the pineal gland and the ovarian bio regulator, but I will say they will do it in conjunction with all the other things that they're doing. So yeah, which is why we started that, exactly. And that's where we start because you've got to be working on your diet, you've got to be working on your stress, you've got to be doing all the things and maybe you need other supplements, maybe you need some hormonal support. But even without hormones, I've seen women get their cycle back. Interesting. So they can be very powerful. But at the same time, I've seen people use a pedal on and deluded and say, well, it didn't do anything for my sleep. I'm like, Okay, what else you doing for your sleep? Because if you're sitting and staring at your screens until one o'clock in the morning, and you think you're gonna pop a pill, and it's gonna fix anything? Actually, it's not. Right. So sometimes it takes longer to see an effect. It always boils down to what's driving the issue in the first place. And what else are you doing to fix that issue?

And that's very individual, isn't it? I mean, like I, I have found that I am super sensitive to screen work or Sweeney's to any kind of evening working to going to the cinema, it will delay sleep for me quite significantly. And just keep me really quite wired. Actually, you know, it's not just like, I just think this stimulation is a lot. I'm curious. I'm curious there when you talk about the pineal gland and its effects on it. Might that improve someone's meditation? Practice and spiritual connection?

Yeah, that's a really good question. And I there are definitely people out there who say that it will I think that it might, but only if you're working consciously towards that goal. Yeah. Right. Yeah. I think that if you're, it's almost like anything, it will it is like anything else. Intention has a lot to do with the an outcome and especially an outcome like that one. I do believe you have to be working towards it. But I will say that people who are using these by regular peptides, and there are now a couple of 100 that are part of a of a study that's being done in the US are seeing material reversals in their biological age. So, you know, it's, it's definitely something to keep an eye on. I don't think there's any downside. Except for to your pocketbook. Yeah, they are a bit of an investment, any way you slice it.

And is it something you would take for a period of time? Or would you take it on an ongoing basis

depends on your goals, and where you're at, right? So let's say someone is 35 years old, and they want to get a jump on things are 30 years old, and they want to get a jump on things. They might say, we might say, okay, like, if you really don't have any health issues going on, and you You're good, maybe what you might do, if you're using the oral bio regulators, you might do a 30 day run of three majors, like the three majors, to me would be the pineal bio regulator, the blood vessel, bio regulator, and the thymus fire regulator. So now we've, we've basically taken addressed immunity, we've addressed blood flow at a macro and micro circulation level without which and you know, the, the blood vessel by a regulator helps to restore function to the endothelium of the of the blood vessels. So we have, we have immunity, we have blood flow. And then we have the pineal gland, which is really kind of like that master orchestra director, if you will. And so as a young person, you might do 30 days, once or twice a year of that group. Right. Now, if you're a high performance athlete, there's a really good chance and we were talking about this before the podcast, high performance athletes often have a much more we think of them as the healthiest people on the planet, they are actually racing to older age, they often have accelerated ageing. And so for those people, they might have to, they might lean into some of the other bio regulators as well to work towards reversing some of the damage of the intense training. But here's the news. It's not really going to do much until you stop the crazy training and kind of start to find some balance there. So it's a bit of a paradox. Definitely. I know that in Russia, they used the bio regulator peptide protocols for the women's gymnastics team, who are all young women, but when they measure their biological age, they notice all of these girls were showing up a lot older than their chronological age. And it's really just the stresses Some strains of competition and training.

So what were they using to assess their biological age.

So they would have been using. I mean, I'm sure they weren't using true diagnostic. And if they weren't using some test of whether they were measuring their telomeres or their DNA methylation now, don't forget that, at the time that they were doing these, those tests were not available commercially to consumers, but the technology for measuring telomeres and whatnot, it's been around for a long time. So at that stage of the game, they were probably availing themselves of that technology, because this started as a project really targeting the military first. And then I'm sure what they started doing is rolling it out to other populations of importance and concern before they made it available to the general population. But apparently, if you go to Russia, you can buy these things in almost, you know, in a, in a corner store, or in a drugstore, maybe a corner store is a bit of a of an exaggeration, but they're not hard to get

interesting. But do we see them having greater healthspan as a result?

I don't know. We don't know. You know, you'd have to

look at them as a population. But then I guess this is the thing with compounding practices now is, you know, all the other things they're doing, potentially drinking a lot of occurs. Well, not not to be too generalistic. But thanks, smokers. And yeah, it makes it

really, you know, I think that if you went and found a population of people in Russia, who are really focused on their health span, and using these things, and not pounding the vodka, and then and the smoking and whatnot, and living a healthy lifestyle, you might see a trend there. But if you go, but you know, what was interesting, you know, actually further to that. I think what was interesting about some of the studies that Professor Kevin son did, particularly on longevity with elderly humans, is that he didn't ask them to change anything. Right. So one group got poly vitamins, and the other group got the epithelium. And so nobody knew what they were getting, nobody was asked to change anything. And the first study he did was with 60 to 74 year old and he followed them for 12 years, they were given the peptides for only two years. And at the end of the 12 years, the group that got the by the bio regulator had, I want to say like 30%, lower rate of all cause mortality than the group that only got the poly vitamins. The second study that he did was 75 to 85 year olds. And now this was a six year study. And again, I believe that he only gave them two years of bio regulators, you had a control group that were given poly vitamins, you had an X group got the Epital on and then a third group got a pedal on and the thymus by regulator violin. And now we see that the first group that got the poly vitamins, now we're talking about much older people. 88%, I think it is, had passed. But after six years, in the group that only got the Epital on, I believe it was, I mean, these are all tables in my presentation. So I don't fully remember all the all the numbers, I think maybe it was trying to remember it was 88%. On the first one, I know it's only 33% mortality on the ones that got epithelium and thymus. So that one made a massive difference massively, and then the epithelium and was somewhere in the middle. And 33. So it was, it was pretty dramatic.

Yeah, profound. I mean, I guess my question is, when I when I look at this stuff, is, are we delaying the inevitable? So the question I have in my mind is in you do I know it's possible because obviously, we see people who just you learn about the fact that they they will find they were in perfect health, they went to sleep one night, and they didn't wake up, which right is a dream, everybody would want that right? Just one day, it just ends like that. Maybe when you get to the end, if we were built for 120, then the system just switches off and you pass on somewhere else. But I guess I'm curious as to your thoughts. Are we are we are improving healthspan but are we delaying the inevitable because, you know, having been through and experience with my with my father, when he passed away, it feels like there can be suffering at the end. And that, I think, is probably the biggest kind of scariest factor, I think, for many people is, you know, yes, this all sounds amazing. And definitely I want to carry on hiking and climbing mountains, all these amazing things, and cross country skiing are all the things that everyone wants to do and travelling the world and seeing grandchildren, great grandchildren. But do we think that we can avoid through doing these things? What what seems to be for many people a predictable period of suffering at the very end, or

or not? I think that's a great question. I think that that goes back to everything else that you're doing. Right? I think that all the chips have to be in place. And so if we want to avoid neurodegenerative diseases, for example, and I'm not saying this is a prescription for avoiding them because nobody has the definitive prescription but there's plenty We have evidence that says, if we can, if we can keep track of and manage our heavy metal exposure, and reduce heavy metal load in the body, we will, we will stand to benefit long term, none of these things happen overnight. All of these things built over decades. So how we feed our bodies, the lifestyle decisions that we make, the all of those things are ultimately going to have a massive impact. The truth of the matter is that we are being bombarded with toxins every day, whether it's electromagnetic frequencies or glyphosate in the food or whatever else, it's it's never ending. So what can we do about that? Let's pay attention to our own pathways of detoxification and help them to work better. Right? So whether that's using the right form of glutathione, understanding genetically, do I have pathways that are less genetically optimised than others? It doesn't mean they're not working. But if we run testing, which we now have access to that can show is my body showing higher levels of oxidative stress? Okay, well, then what are the things I can do to help to reduce that oxidative stress? And what are the things that I'm doing that are contributing to stress that I can maybe reduce? So you know, the other interesting thing about the bio regulators is both the pineal gland bio regulator and another immune by regulator called V, long VI, L O N, both of them are shown to have anti tumour activity. So, maybe they can and it doesn't mean they block it completely, because he did again, he did a bunch of rat studies, and did you know, expose some rats to 24/7 light, and these are rats that are genetically predisposed to developing tumours in the first place. But he was able to show that in rats giving them the pineal gland bio regulator actually reduced the incidence of tumours. And when they did get them, they were smaller. And then, same with, with breast cancer with Brack gene, the bracket gene appeared on and belonged given to rats who had a predisposition to breast cancer, either they had fewer, either they didn't get tumours, or if they did, they were smaller. So there's something in these compounds that is also can be protective. So what it really speaks to is, and this is, you know, it's funny, because you look at Brian Johnson, and here's a man who's put every ounce of energy, every penny, every minute of every hour of every day is devoted to this one goal of slowing down and reversing ageing. And I don't, I mean, look, kudos to him for what he's achieved. For sure. I personally don't think that's a way to live. So I do think that there's, there's a piece of this for us to find, where are where do you want it? How hard are you willing to work for this? What are the things that you can reasonably do so that you can still connect with other people find joy in life, and express yourself, right? Because here's the other piece of longevity, laughing, having a good time, experiencing joy, human connection, love relationships. These things, we know that even in people with cancer, if they have good community around them, if they have good human connections, they often have a better outcome than the next person who's completely isolated. So it's and you know, you asked about my favourite book, and I'd said, you know, it took me a while to think of it. And I came back to this book that I've studied at school when I went back to nutrition school called The Biology of Belief. And the reason why it's a great book, because what it does is it starts with a man who believed that the Sal was everything to human health. Right, all of the secrets of life and health could be found in the cell. And by the end of the book, he's sitting there telling us that what you believe, and the actions and the emotions of your life is going to have as much if not more of an impact on your health, and your outcome than any of the medical things interventions that we have out there. So I think it's so important for all of us to always run because we fall into this trap, right as self defined health hackers biohackers whatever we want to call ourselves optimizers people who are in this field, we keep having to remind ourselves it's all great to sauna and cold plunge and take the supplements and do the technology and zap yourself with this and do yourself with that. But am I having a good time? Am I taking time to actually enjoy my life and connect with people in a meaningful way? Because that's what's going to feed our our energy and our soul energy so So I think to answer your first question, which was can we delay are we only delaying illness care? illness and disease? I don't? I don't think so I think I don't know that we have all the answers yet to avoid them. But I think that as early as we can start to make the right decisions within reason, is going to potentially avoid us dying from a disease and optimise our chances of I mean, you're gonna have to die from something. And I'm not sure that death by Switch is available to us yet. But definitely, I've heard of people dying at a ripe old age relatively quickly, right, like people who, oh my god, he was fine a month ago, and now he's gone. But he's 97 years old. And so we are going to celebrate the amazing life that this person had.

I'm so glad you said that. Because I mean that that's been my personal experience, and kind of where I've gone a lot with my own health. Yes, I do all the wire hugging or all these other things. But the reality is, you know, when I was truly sick in hospital with pneumonia, and I was neutropenic, I had both viral and bacterial pneumonia. So the antibiotics is only going to help one side, right? It's not going to cure the viral side, and I was neutropenic. So there was a very real possibility that I wouldn't have survived it. And at that point, I was so depressed, I had created this prison, in my own mind, I felt this profound sense of peace. And in that moment, within 48 hours of me making a real decision, that I needed to find a way to get to get kind of comfortable with myself and to be there to see my kids grow up. My blood work changed within 48 hours. And that's really what Dr. Bruce Lipton talks about, right? It changes and Joe Dispenza. And they, they were such a massive inspiration to me on my journey. And when I look now, I work a lot with heart rate variability, and using a continuous device and ECG device by Firstbeat. And what I see is that when people are living in alignment, I was having this conversation with Dr. John Demartini, the other day on the podcast. So when people are living in alignment with their values, and they're in sync, heart rate variability improves, and you see resonance, and that I think, as you said, like is such a huge factor in health. And when we look at the Blue Zones, right, how are they living, they're having social connection. They're living in alignment with their, with their purpose and their values. And I think when we are out of sync, that's when problems can occur, potentially. And I think that you know, if we, as you say, if we just focus on all the like, biohacking and restrictive dieting and supplementation and all these things, and fasting and forget about that side of things, we're missing a big piece, and also probably the whole meaning of life in the first place.

100% 100% Yeah, I mean, listen, you can hear these guys saying, I'm gonna lift 180 And I'm like, really? Price.

Exactly. Are you having fun?

Are you having fun yet? And yeah, anyway, it's, I just think, you know, to bring and I love the HRV piece as well, I think to bring balance back to this is are you living well, and, and with joy? But you know, it's also about where are we assigning and getting our pleasure from? Right, if you find your pleasure, if the only place you find your pleasure is a bottle of wine, you're gonna run into some problems at some point. So, you know, doing the work to find joy within ourselves, and in our communities, and all of those things, I think, that's the work we need to be doing. And to your, to your point, living your life's purpose and being in alignment with your life's purpose. And then you do all the other stuff. Right? Then you do do the stuff, like optimising your diet, and, you know, and taking supplements when you need them. You know, there's so many great products out there right now, understanding what should my goal be today? And what am I working towards now? And understanding that, you know, people, like people listen to our podcasts, and they're like, holy jumpin, like, I can't afford all the stuff you talk about. And it all sounds so great. And I'm like, I know, and you're not supposed to use it all the time. You know, everything that we talk about is not going to be the right thing for you. And you don't need to take every single thing every single day. There are those who would argue with me and say, Well, I take 150 pills a day and I'm feeling awesome. And I'd be like, Okay, maybe. I, I, I don't necessarily resonate with that.

I agree. It's been amazing speaking to you. I know there's so much more I think we probably have to, to invite you back. Natalie. I know there's so much more that you could share here. You've really given us just a flavour of the world of longevity and what's available and I know you're at the forefront of it. Where can people connect with you? You have an amazing Facebook community. Please share.

Thank you. So the best you know Knott Central is not nitnem.com That's my website and that's where everything lives. I do have a large Facebook community, I don't spend as much time there as I used to personally, I do have a private membership community, which is on mighty networks. And so when you go to the website, if you go to the top of the page, there's a tab that's BSP community. And that'll take you to learn more about that private membership community. And then I do retreats. I'm doing one this coming November. I don't know when this episode is going to air but if it's before November, our before September, actually, and anybody's interested, it's a women's retreat in the Dominican Republic. And then Instagram is just Natalie net him and my social media person tells me I now have a thread whatever that. And then there's the biohacking superhuman performance podcast as well. But Angela, this has been great. Thank you so much. And I'm looking forward to hosting you on my podcasts because I think we can actually keep this going back and forth. And

oh, that would be fun. I'd love that. Yeah, that would be super fun. Thank you. Thank you so much for coming on. I know I've learned a tonne and I bet everyone listening has and yeah, I'd love to continue the conversation.

Thanks so much.

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